COVID-19 mortality as a fingerprint of biological age

Corona virus disease 2019 (COVID-19) is a global emergency able to overwhelm the healthcare capacities worldwide and to affect the older generation especially. When addressing the pathophysiological mechanisms and clinical manifestations of COVID-19, it becomes evident that the disease targets pathw...

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Autores principales: Polidori, M. Cristina, Sies, Helmut, Ferrucci, Luigi, Benzing, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier B.V. 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7896489/
https://www.ncbi.nlm.nih.gov/pubmed/33621704
http://dx.doi.org/10.1016/j.arr.2021.101308
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author Polidori, M. Cristina
Sies, Helmut
Ferrucci, Luigi
Benzing, Thomas
author_facet Polidori, M. Cristina
Sies, Helmut
Ferrucci, Luigi
Benzing, Thomas
author_sort Polidori, M. Cristina
collection PubMed
description Corona virus disease 2019 (COVID-19) is a global emergency able to overwhelm the healthcare capacities worldwide and to affect the older generation especially. When addressing the pathophysiological mechanisms and clinical manifestations of COVID-19, it becomes evident that the disease targets pathways and domains affected by the main aging- and frailty-related pathophysiological changes. A closer analysis of the existing data supports a possible role of biological age rather than chronological age in the prognosis of COVID-19. There is a need for systematic, consequent action of identifying frail (not only older, not only multimorbid, not only symptomatic) persons at risk of poor outcomes.
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spelling pubmed-78964892021-02-22 COVID-19 mortality as a fingerprint of biological age Polidori, M. Cristina Sies, Helmut Ferrucci, Luigi Benzing, Thomas Ageing Res Rev Review Corona virus disease 2019 (COVID-19) is a global emergency able to overwhelm the healthcare capacities worldwide and to affect the older generation especially. When addressing the pathophysiological mechanisms and clinical manifestations of COVID-19, it becomes evident that the disease targets pathways and domains affected by the main aging- and frailty-related pathophysiological changes. A closer analysis of the existing data supports a possible role of biological age rather than chronological age in the prognosis of COVID-19. There is a need for systematic, consequent action of identifying frail (not only older, not only multimorbid, not only symptomatic) persons at risk of poor outcomes. Published by Elsevier B.V. 2021-05 2021-02-20 /pmc/articles/PMC7896489/ /pubmed/33621704 http://dx.doi.org/10.1016/j.arr.2021.101308 Text en © 2021 Published by Elsevier B.V. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Polidori, M. Cristina
Sies, Helmut
Ferrucci, Luigi
Benzing, Thomas
COVID-19 mortality as a fingerprint of biological age
title COVID-19 mortality as a fingerprint of biological age
title_full COVID-19 mortality as a fingerprint of biological age
title_fullStr COVID-19 mortality as a fingerprint of biological age
title_full_unstemmed COVID-19 mortality as a fingerprint of biological age
title_short COVID-19 mortality as a fingerprint of biological age
title_sort covid-19 mortality as a fingerprint of biological age
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7896489/
https://www.ncbi.nlm.nih.gov/pubmed/33621704
http://dx.doi.org/10.1016/j.arr.2021.101308
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