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Face and object visual working memory deficits in first-episode schizophrenia correlate with multiple neurocognitive performances
BACKGROUND: Working memory (WM) deficit is considered a core feature and cognitive biomarker in patients with schizophrenia. Several studies have reported prominent object WM deficits in patients with schizophrenia, suggesting that visual WM in these patients extends to non-spatial domains. However,...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7896562/ https://www.ncbi.nlm.nih.gov/pubmed/33728399 http://dx.doi.org/10.1136/gpsych-2020-100338 |
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author | Liu, Yi Bi, Taiyong Zhang, Bei Kuang, Qijie Li, Haijing Zong, Kunlun Zhao, Jingping Ning, Yuping She, Shenglin Zheng, Yingjun |
author_facet | Liu, Yi Bi, Taiyong Zhang, Bei Kuang, Qijie Li, Haijing Zong, Kunlun Zhao, Jingping Ning, Yuping She, Shenglin Zheng, Yingjun |
author_sort | Liu, Yi |
collection | PubMed |
description | BACKGROUND: Working memory (WM) deficit is considered a core feature and cognitive biomarker in patients with schizophrenia. Several studies have reported prominent object WM deficits in patients with schizophrenia, suggesting that visual WM in these patients extends to non-spatial domains. However, whether non-spatial WM is similarly affected remains unclear. AIM: This study primarily aimed to identify the processing of visual object WM in patients with first-episode schizophrenia. METHODS: The study included 36 patients with first-episode schizophrenia and 35 healthy controls. Visual object WM capacity, including face and house WM capacity, was assessed by means of delayed matching-to-sample visual WM tasks, in which participants must distribute memory so that they can discriminate a target sample. We specifically examined their anhedonia experience by the Temporal Experience of Pleasure Scale and the Snaith-Hamilton Pleasure Scale. Cognitive performance was measured by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). RESULTS: Both face and house WM capacity was significantly impaired in patients with schizophrenia. For both tasks, the performance of all the subjects was worse under the high-load condition than under the low-load condition. We found that WM capacity was highly positively correlated with the performance on RBANS total scores (r=−0.528, p=0.005), RBANS delayed memory scores (r=−0.470, p=0.013), RBANS attention scores (r=−0.584, p=0.001), RBANS language scores (r=−0.448, p=0.019), Trail-Making Test: Part A raw scores (r=0.465, p=0.015) and simple IQ total scores (r=−0.538, p=0.005), and correlated with scores of the vocabulary test (r=−0.490, p=0.011) and scores of the Block Diagram Test (r=−0.426, p=0.027) in schizophrenia. No significant correlations were observed between WM capacity and Positive and Negative Syndrome Scale symptoms. CONCLUSIONS: Our research found that visual object WM capacity is dramatically impaired in patients with schizophrenia and is strongly correlated with other measures of cognition, suggesting a mechanism that is critical in explaining a portion of the broad cognitive deficits observed in schizophrenia. |
format | Online Article Text |
id | pubmed-7896562 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-78965622021-03-15 Face and object visual working memory deficits in first-episode schizophrenia correlate with multiple neurocognitive performances Liu, Yi Bi, Taiyong Zhang, Bei Kuang, Qijie Li, Haijing Zong, Kunlun Zhao, Jingping Ning, Yuping She, Shenglin Zheng, Yingjun Gen Psychiatr Original Research BACKGROUND: Working memory (WM) deficit is considered a core feature and cognitive biomarker in patients with schizophrenia. Several studies have reported prominent object WM deficits in patients with schizophrenia, suggesting that visual WM in these patients extends to non-spatial domains. However, whether non-spatial WM is similarly affected remains unclear. AIM: This study primarily aimed to identify the processing of visual object WM in patients with first-episode schizophrenia. METHODS: The study included 36 patients with first-episode schizophrenia and 35 healthy controls. Visual object WM capacity, including face and house WM capacity, was assessed by means of delayed matching-to-sample visual WM tasks, in which participants must distribute memory so that they can discriminate a target sample. We specifically examined their anhedonia experience by the Temporal Experience of Pleasure Scale and the Snaith-Hamilton Pleasure Scale. Cognitive performance was measured by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). RESULTS: Both face and house WM capacity was significantly impaired in patients with schizophrenia. For both tasks, the performance of all the subjects was worse under the high-load condition than under the low-load condition. We found that WM capacity was highly positively correlated with the performance on RBANS total scores (r=−0.528, p=0.005), RBANS delayed memory scores (r=−0.470, p=0.013), RBANS attention scores (r=−0.584, p=0.001), RBANS language scores (r=−0.448, p=0.019), Trail-Making Test: Part A raw scores (r=0.465, p=0.015) and simple IQ total scores (r=−0.538, p=0.005), and correlated with scores of the vocabulary test (r=−0.490, p=0.011) and scores of the Block Diagram Test (r=−0.426, p=0.027) in schizophrenia. No significant correlations were observed between WM capacity and Positive and Negative Syndrome Scale symptoms. CONCLUSIONS: Our research found that visual object WM capacity is dramatically impaired in patients with schizophrenia and is strongly correlated with other measures of cognition, suggesting a mechanism that is critical in explaining a portion of the broad cognitive deficits observed in schizophrenia. BMJ Publishing Group 2021-02-18 /pmc/articles/PMC7896562/ /pubmed/33728399 http://dx.doi.org/10.1136/gpsych-2020-100338 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Original Research Liu, Yi Bi, Taiyong Zhang, Bei Kuang, Qijie Li, Haijing Zong, Kunlun Zhao, Jingping Ning, Yuping She, Shenglin Zheng, Yingjun Face and object visual working memory deficits in first-episode schizophrenia correlate with multiple neurocognitive performances |
title | Face and object visual working memory deficits in first-episode schizophrenia correlate with multiple neurocognitive performances |
title_full | Face and object visual working memory deficits in first-episode schizophrenia correlate with multiple neurocognitive performances |
title_fullStr | Face and object visual working memory deficits in first-episode schizophrenia correlate with multiple neurocognitive performances |
title_full_unstemmed | Face and object visual working memory deficits in first-episode schizophrenia correlate with multiple neurocognitive performances |
title_short | Face and object visual working memory deficits in first-episode schizophrenia correlate with multiple neurocognitive performances |
title_sort | face and object visual working memory deficits in first-episode schizophrenia correlate with multiple neurocognitive performances |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7896562/ https://www.ncbi.nlm.nih.gov/pubmed/33728399 http://dx.doi.org/10.1136/gpsych-2020-100338 |
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