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SRP-positive necrotising myopathy: takes more than just the muscles

Necrotising myopathy is an autoimmune disease that commonly affects muscles. Here we examine a case of a middle-aged women presenting with a chief report of shortness of breath, who subsequently developed muscle weakness. Her clinical course was complicated by respiratory failure and pulmonary hyper...

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Detalles Bibliográficos
Autores principales: Below, Samantha, Bashir, Maaman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7896596/
https://www.ncbi.nlm.nih.gov/pubmed/33608334
http://dx.doi.org/10.1136/bcr-2020-237647
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author Below, Samantha
Bashir, Maaman
author_facet Below, Samantha
Bashir, Maaman
author_sort Below, Samantha
collection PubMed
description Necrotising myopathy is an autoimmune disease that commonly affects muscles. Here we examine a case of a middle-aged women presenting with a chief report of shortness of breath, who subsequently developed muscle weakness. Her clinical course was complicated by respiratory failure and pulmonary hypertension likely due to the underlying pathology of signal recognition particle-positive necrotising myopathy. After further evaluation, her shortness of breath was thought to be secondary to muscle pathology rather than cardiopulmonary pathology. She was transferred to our institution for workup by rheumatology. At the time of admission, 6 months after initial presentation, her weakness progressed, so that she was unable to lift her arms and legs against gravity. Furthermore, neurological examination revealed mild facial and nuchal weakness, severe proximal weakness, more moderate distal weakness and global areflexia.
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spelling pubmed-78965962021-03-05 SRP-positive necrotising myopathy: takes more than just the muscles Below, Samantha Bashir, Maaman BMJ Case Rep Case Report Necrotising myopathy is an autoimmune disease that commonly affects muscles. Here we examine a case of a middle-aged women presenting with a chief report of shortness of breath, who subsequently developed muscle weakness. Her clinical course was complicated by respiratory failure and pulmonary hypertension likely due to the underlying pathology of signal recognition particle-positive necrotising myopathy. After further evaluation, her shortness of breath was thought to be secondary to muscle pathology rather than cardiopulmonary pathology. She was transferred to our institution for workup by rheumatology. At the time of admission, 6 months after initial presentation, her weakness progressed, so that she was unable to lift her arms and legs against gravity. Furthermore, neurological examination revealed mild facial and nuchal weakness, severe proximal weakness, more moderate distal weakness and global areflexia. BMJ Publishing Group 2021-02-19 /pmc/articles/PMC7896596/ /pubmed/33608334 http://dx.doi.org/10.1136/bcr-2020-237647 Text en © BMJ Publishing Group Limited 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Case Report
Below, Samantha
Bashir, Maaman
SRP-positive necrotising myopathy: takes more than just the muscles
title SRP-positive necrotising myopathy: takes more than just the muscles
title_full SRP-positive necrotising myopathy: takes more than just the muscles
title_fullStr SRP-positive necrotising myopathy: takes more than just the muscles
title_full_unstemmed SRP-positive necrotising myopathy: takes more than just the muscles
title_short SRP-positive necrotising myopathy: takes more than just the muscles
title_sort srp-positive necrotising myopathy: takes more than just the muscles
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7896596/
https://www.ncbi.nlm.nih.gov/pubmed/33608334
http://dx.doi.org/10.1136/bcr-2020-237647
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