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SRP-positive necrotising myopathy: takes more than just the muscles
Necrotising myopathy is an autoimmune disease that commonly affects muscles. Here we examine a case of a middle-aged women presenting with a chief report of shortness of breath, who subsequently developed muscle weakness. Her clinical course was complicated by respiratory failure and pulmonary hyper...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7896596/ https://www.ncbi.nlm.nih.gov/pubmed/33608334 http://dx.doi.org/10.1136/bcr-2020-237647 |
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author | Below, Samantha Bashir, Maaman |
author_facet | Below, Samantha Bashir, Maaman |
author_sort | Below, Samantha |
collection | PubMed |
description | Necrotising myopathy is an autoimmune disease that commonly affects muscles. Here we examine a case of a middle-aged women presenting with a chief report of shortness of breath, who subsequently developed muscle weakness. Her clinical course was complicated by respiratory failure and pulmonary hypertension likely due to the underlying pathology of signal recognition particle-positive necrotising myopathy. After further evaluation, her shortness of breath was thought to be secondary to muscle pathology rather than cardiopulmonary pathology. She was transferred to our institution for workup by rheumatology. At the time of admission, 6 months after initial presentation, her weakness progressed, so that she was unable to lift her arms and legs against gravity. Furthermore, neurological examination revealed mild facial and nuchal weakness, severe proximal weakness, more moderate distal weakness and global areflexia. |
format | Online Article Text |
id | pubmed-7896596 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-78965962021-03-05 SRP-positive necrotising myopathy: takes more than just the muscles Below, Samantha Bashir, Maaman BMJ Case Rep Case Report Necrotising myopathy is an autoimmune disease that commonly affects muscles. Here we examine a case of a middle-aged women presenting with a chief report of shortness of breath, who subsequently developed muscle weakness. Her clinical course was complicated by respiratory failure and pulmonary hypertension likely due to the underlying pathology of signal recognition particle-positive necrotising myopathy. After further evaluation, her shortness of breath was thought to be secondary to muscle pathology rather than cardiopulmonary pathology. She was transferred to our institution for workup by rheumatology. At the time of admission, 6 months after initial presentation, her weakness progressed, so that she was unable to lift her arms and legs against gravity. Furthermore, neurological examination revealed mild facial and nuchal weakness, severe proximal weakness, more moderate distal weakness and global areflexia. BMJ Publishing Group 2021-02-19 /pmc/articles/PMC7896596/ /pubmed/33608334 http://dx.doi.org/10.1136/bcr-2020-237647 Text en © BMJ Publishing Group Limited 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Case Report Below, Samantha Bashir, Maaman SRP-positive necrotising myopathy: takes more than just the muscles |
title | SRP-positive necrotising myopathy: takes more than just the muscles |
title_full | SRP-positive necrotising myopathy: takes more than just the muscles |
title_fullStr | SRP-positive necrotising myopathy: takes more than just the muscles |
title_full_unstemmed | SRP-positive necrotising myopathy: takes more than just the muscles |
title_short | SRP-positive necrotising myopathy: takes more than just the muscles |
title_sort | srp-positive necrotising myopathy: takes more than just the muscles |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7896596/ https://www.ncbi.nlm.nih.gov/pubmed/33608334 http://dx.doi.org/10.1136/bcr-2020-237647 |
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