Concomitant Treatment of Chronic Hepatitis C With Direct-Acting Antivirals and Multidrug-Resistant Tuberculosis Is Effective and Safe

We assessed effectiveness and safety of concomitant chronic hepatitis C virus (HCV) treatment with direct-acting antivirals (DAAs) and multidrug-resistant tuberculosis (MDR-TB). Of 322 MDR-TB patients (19.4% HCV), 30 were treated concomitantly (23.3% human immunodeficiency virus-positive). Overall,...

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Autores principales: Melikyan, Nara, Huerga, Helena, Atshemyan, Hakob, Kirakosyan, Ohanna, Sargsyants, Narina, Aydinyan, Tsovinar, Saribekyan, Nora, Khachatryan, Naira, Oganezova, Izabella, Falcao, Joana, Balkan, Suna, Hewison, Cathy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7896641/
https://www.ncbi.nlm.nih.gov/pubmed/33634203
http://dx.doi.org/10.1093/ofid/ofaa653
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author Melikyan, Nara
Huerga, Helena
Atshemyan, Hakob
Kirakosyan, Ohanna
Sargsyants, Narina
Aydinyan, Tsovinar
Saribekyan, Nora
Khachatryan, Naira
Oganezova, Izabella
Falcao, Joana
Balkan, Suna
Hewison, Cathy
author_facet Melikyan, Nara
Huerga, Helena
Atshemyan, Hakob
Kirakosyan, Ohanna
Sargsyants, Narina
Aydinyan, Tsovinar
Saribekyan, Nora
Khachatryan, Naira
Oganezova, Izabella
Falcao, Joana
Balkan, Suna
Hewison, Cathy
author_sort Melikyan, Nara
collection PubMed
description We assessed effectiveness and safety of concomitant chronic hepatitis C virus (HCV) treatment with direct-acting antivirals (DAAs) and multidrug-resistant tuberculosis (MDR-TB). Of 322 MDR-TB patients (19.4% HCV), 30 were treated concomitantly (23.3% human immunodeficiency virus-positive). Overall, 76.7% achieved HCV treatment success (95.8% among tested). One patient (3.3%) experienced a serious adverse event.
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spelling pubmed-78966412021-02-24 Concomitant Treatment of Chronic Hepatitis C With Direct-Acting Antivirals and Multidrug-Resistant Tuberculosis Is Effective and Safe Melikyan, Nara Huerga, Helena Atshemyan, Hakob Kirakosyan, Ohanna Sargsyants, Narina Aydinyan, Tsovinar Saribekyan, Nora Khachatryan, Naira Oganezova, Izabella Falcao, Joana Balkan, Suna Hewison, Cathy Open Forum Infect Dis Brief Reports We assessed effectiveness and safety of concomitant chronic hepatitis C virus (HCV) treatment with direct-acting antivirals (DAAs) and multidrug-resistant tuberculosis (MDR-TB). Of 322 MDR-TB patients (19.4% HCV), 30 were treated concomitantly (23.3% human immunodeficiency virus-positive). Overall, 76.7% achieved HCV treatment success (95.8% among tested). One patient (3.3%) experienced a serious adverse event. Oxford University Press 2021-01-04 /pmc/articles/PMC7896641/ /pubmed/33634203 http://dx.doi.org/10.1093/ofid/ofaa653 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Reports
Melikyan, Nara
Huerga, Helena
Atshemyan, Hakob
Kirakosyan, Ohanna
Sargsyants, Narina
Aydinyan, Tsovinar
Saribekyan, Nora
Khachatryan, Naira
Oganezova, Izabella
Falcao, Joana
Balkan, Suna
Hewison, Cathy
Concomitant Treatment of Chronic Hepatitis C With Direct-Acting Antivirals and Multidrug-Resistant Tuberculosis Is Effective and Safe
title Concomitant Treatment of Chronic Hepatitis C With Direct-Acting Antivirals and Multidrug-Resistant Tuberculosis Is Effective and Safe
title_full Concomitant Treatment of Chronic Hepatitis C With Direct-Acting Antivirals and Multidrug-Resistant Tuberculosis Is Effective and Safe
title_fullStr Concomitant Treatment of Chronic Hepatitis C With Direct-Acting Antivirals and Multidrug-Resistant Tuberculosis Is Effective and Safe
title_full_unstemmed Concomitant Treatment of Chronic Hepatitis C With Direct-Acting Antivirals and Multidrug-Resistant Tuberculosis Is Effective and Safe
title_short Concomitant Treatment of Chronic Hepatitis C With Direct-Acting Antivirals and Multidrug-Resistant Tuberculosis Is Effective and Safe
title_sort concomitant treatment of chronic hepatitis c with direct-acting antivirals and multidrug-resistant tuberculosis is effective and safe
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7896641/
https://www.ncbi.nlm.nih.gov/pubmed/33634203
http://dx.doi.org/10.1093/ofid/ofaa653
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