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Do medullary thyroid carcinoma patients with high calcitonin require bilateral neck lymph node clearance? A case report

BACKGROUND: In clinical work, 85%-90% of malignant thyroid diseases are papillary thyroid cancer (PTC); thus, clinicians neglect other types of thyroid cancer, such as medullary thyroid carcinoma (MTC). CASE SUMMARY: We report a 53-year-old female patient with a preoperative calcitonin level of 345...

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Autores principales: Gan, Feng-Jiao, Zhou, Tie, Wu, Shun, Xu, Meng-Xi, Sun, Su-Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7896685/
https://www.ncbi.nlm.nih.gov/pubmed/33644201
http://dx.doi.org/10.12998/wjcc.v9.i6.1343
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author Gan, Feng-Jiao
Zhou, Tie
Wu, Shun
Xu, Meng-Xi
Sun, Su-Hong
author_facet Gan, Feng-Jiao
Zhou, Tie
Wu, Shun
Xu, Meng-Xi
Sun, Su-Hong
author_sort Gan, Feng-Jiao
collection PubMed
description BACKGROUND: In clinical work, 85%-90% of malignant thyroid diseases are papillary thyroid cancer (PTC); thus, clinicians neglect other types of thyroid cancer, such as medullary thyroid carcinoma (MTC). CASE SUMMARY: We report a 53-year-old female patient with a preoperative calcitonin level of 345 pg/mL. There was no definitive diagnosis of MTC by preoperative fine-needle aspiration cytology or intraoperative frozen pathology, but the presence of PTC and MTC was confirmed by postoperative paraffin pathology. The patient underwent total thyroidectomy and bilateral central lymph node dissection. Close follow-up at 1.5 years after surgery revealed no signs of recurrence or metastasis. CONCLUSION: The issue in clinical work-up regarding types of thyroid cancer provides a novel and challenging idea for the surgical treatment of MTC. In the absence of central lymph node metastasis, it is worth addressing whether patients with high calcitonin can undergo total thyroidectomy and bilateral central lymph node dissection without bilateral lateral neck lymph node dissection.
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spelling pubmed-78966852021-02-26 Do medullary thyroid carcinoma patients with high calcitonin require bilateral neck lymph node clearance? A case report Gan, Feng-Jiao Zhou, Tie Wu, Shun Xu, Meng-Xi Sun, Su-Hong World J Clin Cases Case Report BACKGROUND: In clinical work, 85%-90% of malignant thyroid diseases are papillary thyroid cancer (PTC); thus, clinicians neglect other types of thyroid cancer, such as medullary thyroid carcinoma (MTC). CASE SUMMARY: We report a 53-year-old female patient with a preoperative calcitonin level of 345 pg/mL. There was no definitive diagnosis of MTC by preoperative fine-needle aspiration cytology or intraoperative frozen pathology, but the presence of PTC and MTC was confirmed by postoperative paraffin pathology. The patient underwent total thyroidectomy and bilateral central lymph node dissection. Close follow-up at 1.5 years after surgery revealed no signs of recurrence or metastasis. CONCLUSION: The issue in clinical work-up regarding types of thyroid cancer provides a novel and challenging idea for the surgical treatment of MTC. In the absence of central lymph node metastasis, it is worth addressing whether patients with high calcitonin can undergo total thyroidectomy and bilateral central lymph node dissection without bilateral lateral neck lymph node dissection. Baishideng Publishing Group Inc 2021-02-26 2021-02-26 /pmc/articles/PMC7896685/ /pubmed/33644201 http://dx.doi.org/10.12998/wjcc.v9.i6.1343 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Case Report
Gan, Feng-Jiao
Zhou, Tie
Wu, Shun
Xu, Meng-Xi
Sun, Su-Hong
Do medullary thyroid carcinoma patients with high calcitonin require bilateral neck lymph node clearance? A case report
title Do medullary thyroid carcinoma patients with high calcitonin require bilateral neck lymph node clearance? A case report
title_full Do medullary thyroid carcinoma patients with high calcitonin require bilateral neck lymph node clearance? A case report
title_fullStr Do medullary thyroid carcinoma patients with high calcitonin require bilateral neck lymph node clearance? A case report
title_full_unstemmed Do medullary thyroid carcinoma patients with high calcitonin require bilateral neck lymph node clearance? A case report
title_short Do medullary thyroid carcinoma patients with high calcitonin require bilateral neck lymph node clearance? A case report
title_sort do medullary thyroid carcinoma patients with high calcitonin require bilateral neck lymph node clearance? a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7896685/
https://www.ncbi.nlm.nih.gov/pubmed/33644201
http://dx.doi.org/10.12998/wjcc.v9.i6.1343
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