Cargando…

Genomic adaptations to cereal‐based diets contribute to mitigate metabolic risk in some human populations of East Asian ancestry

Adoption of diets based on some cereals, especially on rice, signified an iconic change in nutritional habits for many Asian populations and a relevant challenge for their capability to maintain glucose homeostasis. Indeed, rice shows the highest carbohydrates content and glycemic index among the do...

Descripción completa

Detalles Bibliográficos
Autores principales: Landini, Arianna, Yu, Shaobo, Gnecchi‐Ruscone, Guido Alberto, Abondio, Paolo, Ojeda‐Granados, Claudia, Sarno, Stefania, De Fanti, Sara, Gentilini, Davide, Di Blasio, Anna Maria, Jin, Hanjun, Nguyen, Thanh Tin, Romeo, Giovanni, Prata, Cecilia, Bortolini, Eugenio, Luiselli, Donata, Pettener, Davide, Sazzini, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7896717/
https://www.ncbi.nlm.nih.gov/pubmed/33664777
http://dx.doi.org/10.1111/eva.13090
_version_ 1783653595873280000
author Landini, Arianna
Yu, Shaobo
Gnecchi‐Ruscone, Guido Alberto
Abondio, Paolo
Ojeda‐Granados, Claudia
Sarno, Stefania
De Fanti, Sara
Gentilini, Davide
Di Blasio, Anna Maria
Jin, Hanjun
Nguyen, Thanh Tin
Romeo, Giovanni
Prata, Cecilia
Bortolini, Eugenio
Luiselli, Donata
Pettener, Davide
Sazzini, Marco
author_facet Landini, Arianna
Yu, Shaobo
Gnecchi‐Ruscone, Guido Alberto
Abondio, Paolo
Ojeda‐Granados, Claudia
Sarno, Stefania
De Fanti, Sara
Gentilini, Davide
Di Blasio, Anna Maria
Jin, Hanjun
Nguyen, Thanh Tin
Romeo, Giovanni
Prata, Cecilia
Bortolini, Eugenio
Luiselli, Donata
Pettener, Davide
Sazzini, Marco
author_sort Landini, Arianna
collection PubMed
description Adoption of diets based on some cereals, especially on rice, signified an iconic change in nutritional habits for many Asian populations and a relevant challenge for their capability to maintain glucose homeostasis. Indeed, rice shows the highest carbohydrates content and glycemic index among the domesticated cereals and its usual ingestion represents a potential risk factor for developing insulin resistance and related metabolic diseases. Nevertheless, type 2 diabetes and obesity epidemiological patterns differ among Asian populations that rely on rice as a staple food, with higher diabetes prevalence and increased levels of central adiposity observed in people of South Asian ancestry rather than in East Asians. This may be at least partly due to the fact that populations from East Asian regions where wild rice or other cereals such as millet have been already consumed before their cultivation and/or were early domesticated have relied on these nutritional resources for a period long enough to have possibly evolved biological adaptations that counteract their detrimental side effects. To test such a hypothesis, we compared adaptive evolution of these populations with that of control groups from regions where the adoption of cereal‐based diets occurred many thousand years later and which were identified from a genome‐wide dataset including 2,379 individuals from 124 East Asian and South Asian populations. This revealed selective sweeps and polygenic adaptive mechanisms affecting functional pathways involved in fatty acids metabolism, cholesterol/triglycerides biosynthesis from carbohydrates, regulation of glucose homeostasis, and production of retinoic acid in Chinese Han and Tujia ethnic groups, as well as in people of Korean and Japanese ancestry. Accordingly, long‐standing rice‐ and/or millet‐based diets have possibly contributed to trigger the evolution of such biological adaptations, which might represent one of the factors that play a role in mitigating the metabolic risk of these East Asian populations.
format Online
Article
Text
id pubmed-7896717
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-78967172021-03-03 Genomic adaptations to cereal‐based diets contribute to mitigate metabolic risk in some human populations of East Asian ancestry Landini, Arianna Yu, Shaobo Gnecchi‐Ruscone, Guido Alberto Abondio, Paolo Ojeda‐Granados, Claudia Sarno, Stefania De Fanti, Sara Gentilini, Davide Di Blasio, Anna Maria Jin, Hanjun Nguyen, Thanh Tin Romeo, Giovanni Prata, Cecilia Bortolini, Eugenio Luiselli, Donata Pettener, Davide Sazzini, Marco Evol Appl Original Articles Adoption of diets based on some cereals, especially on rice, signified an iconic change in nutritional habits for many Asian populations and a relevant challenge for their capability to maintain glucose homeostasis. Indeed, rice shows the highest carbohydrates content and glycemic index among the domesticated cereals and its usual ingestion represents a potential risk factor for developing insulin resistance and related metabolic diseases. Nevertheless, type 2 diabetes and obesity epidemiological patterns differ among Asian populations that rely on rice as a staple food, with higher diabetes prevalence and increased levels of central adiposity observed in people of South Asian ancestry rather than in East Asians. This may be at least partly due to the fact that populations from East Asian regions where wild rice or other cereals such as millet have been already consumed before their cultivation and/or were early domesticated have relied on these nutritional resources for a period long enough to have possibly evolved biological adaptations that counteract their detrimental side effects. To test such a hypothesis, we compared adaptive evolution of these populations with that of control groups from regions where the adoption of cereal‐based diets occurred many thousand years later and which were identified from a genome‐wide dataset including 2,379 individuals from 124 East Asian and South Asian populations. This revealed selective sweeps and polygenic adaptive mechanisms affecting functional pathways involved in fatty acids metabolism, cholesterol/triglycerides biosynthesis from carbohydrates, regulation of glucose homeostasis, and production of retinoic acid in Chinese Han and Tujia ethnic groups, as well as in people of Korean and Japanese ancestry. Accordingly, long‐standing rice‐ and/or millet‐based diets have possibly contributed to trigger the evolution of such biological adaptations, which might represent one of the factors that play a role in mitigating the metabolic risk of these East Asian populations. John Wiley and Sons Inc. 2020-09-08 /pmc/articles/PMC7896717/ /pubmed/33664777 http://dx.doi.org/10.1111/eva.13090 Text en © 2020 The Authors. Evolutionary Applications published by John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Landini, Arianna
Yu, Shaobo
Gnecchi‐Ruscone, Guido Alberto
Abondio, Paolo
Ojeda‐Granados, Claudia
Sarno, Stefania
De Fanti, Sara
Gentilini, Davide
Di Blasio, Anna Maria
Jin, Hanjun
Nguyen, Thanh Tin
Romeo, Giovanni
Prata, Cecilia
Bortolini, Eugenio
Luiselli, Donata
Pettener, Davide
Sazzini, Marco
Genomic adaptations to cereal‐based diets contribute to mitigate metabolic risk in some human populations of East Asian ancestry
title Genomic adaptations to cereal‐based diets contribute to mitigate metabolic risk in some human populations of East Asian ancestry
title_full Genomic adaptations to cereal‐based diets contribute to mitigate metabolic risk in some human populations of East Asian ancestry
title_fullStr Genomic adaptations to cereal‐based diets contribute to mitigate metabolic risk in some human populations of East Asian ancestry
title_full_unstemmed Genomic adaptations to cereal‐based diets contribute to mitigate metabolic risk in some human populations of East Asian ancestry
title_short Genomic adaptations to cereal‐based diets contribute to mitigate metabolic risk in some human populations of East Asian ancestry
title_sort genomic adaptations to cereal‐based diets contribute to mitigate metabolic risk in some human populations of east asian ancestry
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7896717/
https://www.ncbi.nlm.nih.gov/pubmed/33664777
http://dx.doi.org/10.1111/eva.13090
work_keys_str_mv AT landiniarianna genomicadaptationstocerealbaseddietscontributetomitigatemetabolicriskinsomehumanpopulationsofeastasianancestry
AT yushaobo genomicadaptationstocerealbaseddietscontributetomitigatemetabolicriskinsomehumanpopulationsofeastasianancestry
AT gnecchirusconeguidoalberto genomicadaptationstocerealbaseddietscontributetomitigatemetabolicriskinsomehumanpopulationsofeastasianancestry
AT abondiopaolo genomicadaptationstocerealbaseddietscontributetomitigatemetabolicriskinsomehumanpopulationsofeastasianancestry
AT ojedagranadosclaudia genomicadaptationstocerealbaseddietscontributetomitigatemetabolicriskinsomehumanpopulationsofeastasianancestry
AT sarnostefania genomicadaptationstocerealbaseddietscontributetomitigatemetabolicriskinsomehumanpopulationsofeastasianancestry
AT defantisara genomicadaptationstocerealbaseddietscontributetomitigatemetabolicriskinsomehumanpopulationsofeastasianancestry
AT gentilinidavide genomicadaptationstocerealbaseddietscontributetomitigatemetabolicriskinsomehumanpopulationsofeastasianancestry
AT diblasioannamaria genomicadaptationstocerealbaseddietscontributetomitigatemetabolicriskinsomehumanpopulationsofeastasianancestry
AT jinhanjun genomicadaptationstocerealbaseddietscontributetomitigatemetabolicriskinsomehumanpopulationsofeastasianancestry
AT nguyenthanhtin genomicadaptationstocerealbaseddietscontributetomitigatemetabolicriskinsomehumanpopulationsofeastasianancestry
AT romeogiovanni genomicadaptationstocerealbaseddietscontributetomitigatemetabolicriskinsomehumanpopulationsofeastasianancestry
AT pratacecilia genomicadaptationstocerealbaseddietscontributetomitigatemetabolicriskinsomehumanpopulationsofeastasianancestry
AT bortolinieugenio genomicadaptationstocerealbaseddietscontributetomitigatemetabolicriskinsomehumanpopulationsofeastasianancestry
AT luisellidonata genomicadaptationstocerealbaseddietscontributetomitigatemetabolicriskinsomehumanpopulationsofeastasianancestry
AT pettenerdavide genomicadaptationstocerealbaseddietscontributetomitigatemetabolicriskinsomehumanpopulationsofeastasianancestry
AT sazzinimarco genomicadaptationstocerealbaseddietscontributetomitigatemetabolicriskinsomehumanpopulationsofeastasianancestry