Cargando…
The effect of the mGlu8 receptor agonist, (S)-3,4-DCPG on acquisition and expression of morphine-induced conditioned place preference in male rats
BACKGROUND: The nucleus accumbens (NAc) plays a principal role in drug reward. It has been reported that metabotropic glutamate receptors (mGlu receptors) play a key role in the rewarding pathway(s). Previous studies have shown the vast allocation of the different types of mGlu receptors, including...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897377/ https://www.ncbi.nlm.nih.gov/pubmed/33612106 http://dx.doi.org/10.1186/s12993-021-00174-0 |
_version_ | 1783653658023428096 |
---|---|
author | Kahvandi, Nazanin Ebrahimi, Zahra Karimi, Seyed Asaad Shahidi, Siamak Salehi, Iraj Naderishahab, Marzieh Sarihi, Abdolrahman |
author_facet | Kahvandi, Nazanin Ebrahimi, Zahra Karimi, Seyed Asaad Shahidi, Siamak Salehi, Iraj Naderishahab, Marzieh Sarihi, Abdolrahman |
author_sort | Kahvandi, Nazanin |
collection | PubMed |
description | BACKGROUND: The nucleus accumbens (NAc) plays a principal role in drug reward. It has been reported that metabotropic glutamate receptors (mGlu receptors) play a key role in the rewarding pathway(s). Previous studies have shown the vast allocation of the different types of mGlu receptors, including mGlu8 receptors, in regions that are associated with opioid rewards, such as the NAc. The aim of the present study was to evaluate the role of mGlu8 receptors within the NAc in the acquisition and expression phases of morphine induced conditioned place preference (CPP). Adult male Wistar rats were bilaterally implanted by two cannulas' in the NAc and were evaluated in a CPP paradigm. Selective mGlu8 receptor allosteric agonist (S-3,4-DCPG) was administered at doses of 0.03, 0.3, and 3 μg/0.5 μL saline per side into the NAc on both sides during the 3 days of morphine (5 mg/kg) conditioning (acquisition) phase, or before place preference test, or post-conditioning (expression) phase of morphine-induced CPP. RESULTS: The results revealed that intra-accumbal administration of S-3,4-DCPG (0.3 and 3 μg) markedly decreased the acquisition in a dose-dependent manner but had no effect on expression of morphine-induced CPP. CONCLUSIONS: The findings suggest that activation of mGlu8 receptors in the NAc dose-dependently blocks the establishment of morphine-induced CPP and reduces the rewarding properties of morphine which may be related to the glutamate activity into the NAc and in reward pathway(s). These data suggest that mGlu8 receptor may be involved in conditioned morphine reward. |
format | Online Article Text |
id | pubmed-7897377 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-78973772021-02-22 The effect of the mGlu8 receptor agonist, (S)-3,4-DCPG on acquisition and expression of morphine-induced conditioned place preference in male rats Kahvandi, Nazanin Ebrahimi, Zahra Karimi, Seyed Asaad Shahidi, Siamak Salehi, Iraj Naderishahab, Marzieh Sarihi, Abdolrahman Behav Brain Funct Research BACKGROUND: The nucleus accumbens (NAc) plays a principal role in drug reward. It has been reported that metabotropic glutamate receptors (mGlu receptors) play a key role in the rewarding pathway(s). Previous studies have shown the vast allocation of the different types of mGlu receptors, including mGlu8 receptors, in regions that are associated with opioid rewards, such as the NAc. The aim of the present study was to evaluate the role of mGlu8 receptors within the NAc in the acquisition and expression phases of morphine induced conditioned place preference (CPP). Adult male Wistar rats were bilaterally implanted by two cannulas' in the NAc and were evaluated in a CPP paradigm. Selective mGlu8 receptor allosteric agonist (S-3,4-DCPG) was administered at doses of 0.03, 0.3, and 3 μg/0.5 μL saline per side into the NAc on both sides during the 3 days of morphine (5 mg/kg) conditioning (acquisition) phase, or before place preference test, or post-conditioning (expression) phase of morphine-induced CPP. RESULTS: The results revealed that intra-accumbal administration of S-3,4-DCPG (0.3 and 3 μg) markedly decreased the acquisition in a dose-dependent manner but had no effect on expression of morphine-induced CPP. CONCLUSIONS: The findings suggest that activation of mGlu8 receptors in the NAc dose-dependently blocks the establishment of morphine-induced CPP and reduces the rewarding properties of morphine which may be related to the glutamate activity into the NAc and in reward pathway(s). These data suggest that mGlu8 receptor may be involved in conditioned morphine reward. BioMed Central 2021-02-21 /pmc/articles/PMC7897377/ /pubmed/33612106 http://dx.doi.org/10.1186/s12993-021-00174-0 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Kahvandi, Nazanin Ebrahimi, Zahra Karimi, Seyed Asaad Shahidi, Siamak Salehi, Iraj Naderishahab, Marzieh Sarihi, Abdolrahman The effect of the mGlu8 receptor agonist, (S)-3,4-DCPG on acquisition and expression of morphine-induced conditioned place preference in male rats |
title | The effect of the mGlu8 receptor agonist, (S)-3,4-DCPG on acquisition and expression of morphine-induced conditioned place preference in male rats |
title_full | The effect of the mGlu8 receptor agonist, (S)-3,4-DCPG on acquisition and expression of morphine-induced conditioned place preference in male rats |
title_fullStr | The effect of the mGlu8 receptor agonist, (S)-3,4-DCPG on acquisition and expression of morphine-induced conditioned place preference in male rats |
title_full_unstemmed | The effect of the mGlu8 receptor agonist, (S)-3,4-DCPG on acquisition and expression of morphine-induced conditioned place preference in male rats |
title_short | The effect of the mGlu8 receptor agonist, (S)-3,4-DCPG on acquisition and expression of morphine-induced conditioned place preference in male rats |
title_sort | effect of the mglu8 receptor agonist, (s)-3,4-dcpg on acquisition and expression of morphine-induced conditioned place preference in male rats |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897377/ https://www.ncbi.nlm.nih.gov/pubmed/33612106 http://dx.doi.org/10.1186/s12993-021-00174-0 |
work_keys_str_mv | AT kahvandinazanin theeffectofthemglu8receptoragonists34dcpgonacquisitionandexpressionofmorphineinducedconditionedplacepreferenceinmalerats AT ebrahimizahra theeffectofthemglu8receptoragonists34dcpgonacquisitionandexpressionofmorphineinducedconditionedplacepreferenceinmalerats AT karimiseyedasaad theeffectofthemglu8receptoragonists34dcpgonacquisitionandexpressionofmorphineinducedconditionedplacepreferenceinmalerats AT shahidisiamak theeffectofthemglu8receptoragonists34dcpgonacquisitionandexpressionofmorphineinducedconditionedplacepreferenceinmalerats AT salehiiraj theeffectofthemglu8receptoragonists34dcpgonacquisitionandexpressionofmorphineinducedconditionedplacepreferenceinmalerats AT naderishahabmarzieh theeffectofthemglu8receptoragonists34dcpgonacquisitionandexpressionofmorphineinducedconditionedplacepreferenceinmalerats AT sarihiabdolrahman theeffectofthemglu8receptoragonists34dcpgonacquisitionandexpressionofmorphineinducedconditionedplacepreferenceinmalerats AT kahvandinazanin effectofthemglu8receptoragonists34dcpgonacquisitionandexpressionofmorphineinducedconditionedplacepreferenceinmalerats AT ebrahimizahra effectofthemglu8receptoragonists34dcpgonacquisitionandexpressionofmorphineinducedconditionedplacepreferenceinmalerats AT karimiseyedasaad effectofthemglu8receptoragonists34dcpgonacquisitionandexpressionofmorphineinducedconditionedplacepreferenceinmalerats AT shahidisiamak effectofthemglu8receptoragonists34dcpgonacquisitionandexpressionofmorphineinducedconditionedplacepreferenceinmalerats AT salehiiraj effectofthemglu8receptoragonists34dcpgonacquisitionandexpressionofmorphineinducedconditionedplacepreferenceinmalerats AT naderishahabmarzieh effectofthemglu8receptoragonists34dcpgonacquisitionandexpressionofmorphineinducedconditionedplacepreferenceinmalerats AT sarihiabdolrahman effectofthemglu8receptoragonists34dcpgonacquisitionandexpressionofmorphineinducedconditionedplacepreferenceinmalerats |