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Inflammatory arthritis in patients with COVID-19

Patients with inflammatory arthritis represent a possible high-risk group to COVID-19 due to their immunosuppressive regimen designed to maintain low disease activity. Thus, substantial effort has been put forth to understand the impact of COVID-19 on these patients. Patients with rheumatic diseases...

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Autores principales: Conway, Richard, Konig, Maximilian F., Graef, Elizabeth R., Webb, Kate, Yazdany, Jinoos, Kim, Alfred H.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897406/
https://www.ncbi.nlm.nih.gov/pubmed/33626415
http://dx.doi.org/10.1016/j.trsl.2021.02.010
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author Conway, Richard
Konig, Maximilian F.
Graef, Elizabeth R.
Webb, Kate
Yazdany, Jinoos
Kim, Alfred H.J.
author_facet Conway, Richard
Konig, Maximilian F.
Graef, Elizabeth R.
Webb, Kate
Yazdany, Jinoos
Kim, Alfred H.J.
author_sort Conway, Richard
collection PubMed
description Patients with inflammatory arthritis represent a possible high-risk group to COVID-19 due to their immunosuppressive regimen designed to maintain low disease activity. Thus, substantial effort has been put forth to understand the impact of COVID-19 on these patients. Patients with rheumatic diseases as a whole do not appear to be more susceptible to acquiring COVID-19. Furthermore, immunosuppression generally did not increase the likelihood of developing severe COVID-19, with the important exception of medium and high-dose glucocorticoid use. In addition, a small number of COVID-19 patients have developed new inflammatory arthritis; whether this represents an unmasking of previous subclinical disease or a bone fide virus-induced arthritis is unclear. Nevertheless, it appears that inflammatory arthritis patients currently on immunosuppression should continue their medication to prevent future flares and limit glucocorticoid usage. While this continues to be a rapidly evolving field, these data are reassuring to both patients with and providers treating inflammatory arthritides.
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spelling pubmed-78974062021-02-22 Inflammatory arthritis in patients with COVID-19 Conway, Richard Konig, Maximilian F. Graef, Elizabeth R. Webb, Kate Yazdany, Jinoos Kim, Alfred H.J. Transl Res Review Article Patients with inflammatory arthritis represent a possible high-risk group to COVID-19 due to their immunosuppressive regimen designed to maintain low disease activity. Thus, substantial effort has been put forth to understand the impact of COVID-19 on these patients. Patients with rheumatic diseases as a whole do not appear to be more susceptible to acquiring COVID-19. Furthermore, immunosuppression generally did not increase the likelihood of developing severe COVID-19, with the important exception of medium and high-dose glucocorticoid use. In addition, a small number of COVID-19 patients have developed new inflammatory arthritis; whether this represents an unmasking of previous subclinical disease or a bone fide virus-induced arthritis is unclear. Nevertheless, it appears that inflammatory arthritis patients currently on immunosuppression should continue their medication to prevent future flares and limit glucocorticoid usage. While this continues to be a rapidly evolving field, these data are reassuring to both patients with and providers treating inflammatory arthritides. Elsevier Inc. 2021-06 2021-02-21 /pmc/articles/PMC7897406/ /pubmed/33626415 http://dx.doi.org/10.1016/j.trsl.2021.02.010 Text en © 2021 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review Article
Conway, Richard
Konig, Maximilian F.
Graef, Elizabeth R.
Webb, Kate
Yazdany, Jinoos
Kim, Alfred H.J.
Inflammatory arthritis in patients with COVID-19
title Inflammatory arthritis in patients with COVID-19
title_full Inflammatory arthritis in patients with COVID-19
title_fullStr Inflammatory arthritis in patients with COVID-19
title_full_unstemmed Inflammatory arthritis in patients with COVID-19
title_short Inflammatory arthritis in patients with COVID-19
title_sort inflammatory arthritis in patients with covid-19
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897406/
https://www.ncbi.nlm.nih.gov/pubmed/33626415
http://dx.doi.org/10.1016/j.trsl.2021.02.010
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