Small molecules inhibitors of the heterogeneous ribonuclear protein A18 (hnRNP A18): a regulator of protein translation and an immune checkpoint

We have identified chemical probes that simultaneously inhibit cancer cell progression and an immune checkpoint. Using the computational Site Identification by Ligand Competitive Saturation (SILCS) technology, structural biology and cell-based assays, we identify small molecules that directly and se...

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Detalles Bibliográficos
Autores principales: Solano-Gonzalez, Eduardo, Coburn, Katherine M, Yu, Wenbo, Wilson, Gerald M, Nurmemmedov, Elmar, Kesari, Santosh, Chang, Elizabeth T, MacKerell, Alexander D, Weber, David J, Carrier, France
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897483/
https://www.ncbi.nlm.nih.gov/pubmed/33398344
http://dx.doi.org/10.1093/nar/gkaa1254

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897483/
https://www.ncbi.nlm.nih.gov/pubmed/33398344
http://dx.doi.org/10.1093/nar/gkaa1254

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