The MRN complex promotes DNA repair by homologous recombination and restrains antigenic variation in African trypanosomes

Homologous recombination dominates as the major form of DNA repair in Trypanosoma brucei, and is especially important for recombination of the subtelomeric variant surface glycoprotein during antigenic variation. RAD50, a component of the MRN complex (MRE11, RAD50, NBS1), is central to homologous re...

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Detalles Bibliográficos
Autores principales: Mehnert, Ann-Kathrin, Prorocic, Marco, Dujeancourt-Henry, Annick, Hutchinson, Sebastian, McCulloch, Richard, Glover, Lucy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897489/
https://www.ncbi.nlm.nih.gov/pubmed/33450001
http://dx.doi.org/10.1093/nar/gkaa1265

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