Non-B DNA: a major contributor to small- and large-scale variation in nucleotide substitution frequencies across the genome

Approximately 13% of the human genome can fold into non-canonical (non-B) DNA structures (e.g. G-quadruplexes, Z-DNA, etc.), which have been implicated in vital cellular processes. Non-B DNA also hinders replication, increasing errors and facilitating mutagenesis, yet its contribution to genome-wide...

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Detalles Bibliográficos
Autores principales: Guiblet, Wilfried M, Cremona, Marzia A, Harris, Robert S, Chen, Di, Eckert, Kristin A, Chiaromonte, Francesca, Huang, Yi-Fei, Makova, Kateryna D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897504/
https://www.ncbi.nlm.nih.gov/pubmed/33450015
http://dx.doi.org/10.1093/nar/gkaa1269

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