Cargando…

Loss of Mediator complex subunit 13 (MED13) promotes resistance to alkylation through cyclin D1 upregulation

Alkylating drugs are among the most often used chemotherapeutics. While cancer cells frequently develop resistance to alkylation treatments, detailed understanding of mechanisms that lead to the resistance is limited. Here, by using genome-wide CRISPR–Cas9 based screen, we identify transcriptional M...

Descripción completa

Detalles Bibliográficos
Autores principales:	Roliński, Miłosz, Montaldo, Nicola Pietro, Aksu, Merdane Ezgi, Fordyce Martin, Sarah L, Brambilla, Alessandro, Kunath, Nicolas, Johansen, Jostein, Erlandsen, Sten Even, Liabbak, Nina-Beate, Rian, Kristin, Bjørås, Magnar, Sætrom, Pål, van Loon, Barbara
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897519/ https://www.ncbi.nlm.nih.gov/pubmed/33444446 http://dx.doi.org/10.1093/nar/gkaa1289

Ejemplares similares

AP endonuclease independent repair of abasic sites in Schizosaccharomyces pombe
por: Nilsen, Line, et al.
Publicado: (2012)

Monitoring of the spatial and temporal dynamics of BER/SSBR pathway proteins, including MYH, UNG2, MPG, NTH1 and NEIL1-3, during DNA replication
por: Bjørås, Karine Ø., et al.
Publicado: (2017)

3CAPS – a structural AP–site analogue as a tool to investigate DNA base excision repair
por: Schuermann, David, et al.
Publicado: (2016)

Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression
por: Montaldo, Nicola P., et al.
Publicado: (2019)

Nuclear import of Cdc13 limits chromosomal capping
por: Mersaoui, Sofiane Y, et al.
Publicado: (2018)

Increased p53 signaling impairs neural differentiation in HUWE1-promoted intellectual disabilities
por: Aprigliano, Rossana, et al.
Publicado: (2021)

Cytotoxic and mutagenic properties of alkyl phosphotriester lesions in Escherichia coli cells
por: Wu, Jiabin, et al.
Publicado: (2018)

Cellular heterogeneity in DNA alkylation repair increases population genetic plasticity
por: Vincent, Maxence S, et al.
Publicado: (2021)

Molecular characterization of an adaptive response to alkylating agents in the opportunistic pathogen Aspergillus fumigatus
por: O’Hanlon, Karen A., et al.
Publicado: (2012)

Ubc13 dosage is critical for immunoglobulin gene conversion and gene targeting in vertebrate cells
por: Ertongur, Isin, et al.
Publicado: (2010)

The Shu complex promotes error-free tolerance of alkylation-induced base excision repair products
por: Godin, Stephen K., et al.
Publicado: (2016)

Combinatorial recognition of a complex telomere repeat sequence by the Candida parapsilosis Cdc13AB heterodimer
por: Steinberg-Neifach, Olga, et al.
Publicado: (2015)

The telomeric Cdc13–Stn1–Ten1 complex regulates RNA polymerase II transcription
por: Calvo, Olga, et al.
Publicado: (2019)

Molecular architecture and oligomerization of Candida glabrata Cdc13 underpin its telomeric DNA-binding and unfolding activity
por: Coloma, Javier, et al.
Publicado: (2023)

Structure-function relationships governing activity and stability of a DNA alkylation damage repair thermostable protein
por: Perugino, Giuseppe, et al.
Publicado: (2015)

The β-1,3-glucanosyltransferase Gas1 regulates Sir2-mediated rDNA stability in Saccharomyces cerevisiae
por: Ha, Cheol Woong, et al.
Publicado: (2014)

Human RAD51 paralogue RAD51C fosters repair of alkylated DNA by interacting with the ALKBH3 demethylase
por: Mohan, Monisha, et al.
Publicado: (2019)

Histone H3 lysine 36 methyltransferase mobilizes NER factors to regulate tolerance against alkylation damage in fission yeast
por: Lim, Kim Kiat, et al.
Publicado: (2018)

Energetic signatures of single base bulges: thermodynamic consequences and biological implications
por: Minetti, Conceição A. S. A., et al.
Publicado: (2010)

A regulatory network comprising let-7 miRNA and SMUG1 is associated with good prognosis in ER(+) breast tumours
por: Lirussi, Lisa, et al.
Publicado: (2022)

DNA secondary structures are associated with recombination in major Plasmodium falciparum variable surface antigen gene families
por: Sander, Adam F., et al.
Publicado: (2014)

Loss of MED12 activates the TGFβ pathway to promote chemoresistance and replication fork stability in BRCA-deficient cells
por: Jackson, Lindsey M, et al.
Publicado: (2021)

Cooperative interaction between AAG and UV-DDB in the removal of modified bases
por: Jang, Sunbok, et al.
Publicado: (2022)

Involvement of Werner syndrome protein in MUTYH-mediated repair of oxidative DNA damage
por: Kanagaraj, Radhakrishnan, et al.
Publicado: (2012)

Silencing of human DNA polymerase λ causes replication stress and is synthetically lethal with an impaired S phase checkpoint
por: Zucca, Elisa, et al.
Publicado: (2013)

The Bloom's syndrome helicase (BLM) interacts physically and functionally with p12, the smallest subunit of human DNA polymerase δ
por: Selak, Nives, et al.
Publicado: (2008)

Ribonucleotide incorporation by human DNA polymerase η impacts translesion synthesis and RNase H2 activity
por: Mentegari, Elisa, et al.
Publicado: (2017)

Evidence for lesion bypass by yeast replicative DNA polymerases during DNA damage
por: Sabouri, Nasim, et al.
Publicado: (2008)

Viral AlkB proteins repair RNA damage by oxidative demethylation
por: van den Born, Erwin, et al.
Publicado: (2008)

DNA replication timing is deterministic at the level of chromosomal domains but stochastic at the level of replicons in Xenopus egg extracts
por: Labit, Hélène, et al.
Publicado: (2008)

The SET and transposase domain protein Metnase enhances chromosome decatenation: regulation by automethylation
por: Williamson, Elizabeth A., et al.
Publicado: (2008)

Editing of misaligned 3′-termini by an intrinsic 3′–5′ exonuclease activity residing in the PHP domain of a family X DNA polymerase
por: Baños, Benito, et al.
Publicado: (2008)

Mutagenicity of tamoxifen DNA adducts in human endometrial cells and in silico prediction of p53 mutation hotspots
por: Liapis, Evagelos, et al.
Publicado: (2008)

Loss of DNA ligase IV prevents recognition of DNA by double-strand break repair proteins XRCC4 and XLF
por: Jayaram, Sumithra, et al.
Publicado: (2008)

Dissecting the role of p53 phosphorylation in homologous recombination provides new clues for gain-of-function mutants
por: Restle, Anja, et al.
Publicado: (2008)

Impact of non-homologous end-joining deficiency on random and targeted DNA integration: implications for gene targeting
por: Iiizumi, Susumu, et al.
Publicado: (2008)

Drosophila bloom helicase maintains genome integrity by inhibiting recombination between divergent DNA sequences
por: Kappeler, Michael, et al.
Publicado: (2008)

REV1 restrains DNA polymerase ζ to ensure frame fidelity during translesion synthesis of UV photoproducts in vivo
por: Szüts, Dávid, et al.
Publicado: (2008)

Identification of the Xenopus DNA2 protein as a major nuclease for the 5′→3′ strand-specific processing of DNA ends
por: Liao, Shuren, et al.
Publicado: (2008)

Rad9 plays an important role in DNA mismatch repair through physical interaction with MLH1
por: He, Wei, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_b59i2j92vqq8tdtakk8m5lloai