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Induction and transmission of oncogene-induced senescence
Senescence is a cellular stress response triggered by diverse stressors, including oncogene activation, where it serves as a bona-fide tumour suppressor mechanism. Senescence can be transmitted to neighbouring cells, known as paracrine secondary senescence. Secondary senescence was initially describ...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897614/ https://www.ncbi.nlm.nih.gov/pubmed/32936311 http://dx.doi.org/10.1007/s00018-020-03638-0 |
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author | Rattanavirotkul, Nattaphong Kirschner, Kristina Chandra, Tamir |
author_facet | Rattanavirotkul, Nattaphong Kirschner, Kristina Chandra, Tamir |
author_sort | Rattanavirotkul, Nattaphong |
collection | PubMed |
description | Senescence is a cellular stress response triggered by diverse stressors, including oncogene activation, where it serves as a bona-fide tumour suppressor mechanism. Senescence can be transmitted to neighbouring cells, known as paracrine secondary senescence. Secondary senescence was initially described as a paracrine mechanism, but recent evidence suggests a more complex scenario involving juxtacrine communication between cells. In addition, single-cell studies described differences between primary and secondary senescent end-points, which have thus far not been considered functionally distinct. Here we discuss emerging concepts in senescence transmission and heterogeneity in primary and secondary senescence on a cellular and organ level. |
format | Online Article Text |
id | pubmed-7897614 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-78976142021-03-05 Induction and transmission of oncogene-induced senescence Rattanavirotkul, Nattaphong Kirschner, Kristina Chandra, Tamir Cell Mol Life Sci Review Senescence is a cellular stress response triggered by diverse stressors, including oncogene activation, where it serves as a bona-fide tumour suppressor mechanism. Senescence can be transmitted to neighbouring cells, known as paracrine secondary senescence. Secondary senescence was initially described as a paracrine mechanism, but recent evidence suggests a more complex scenario involving juxtacrine communication between cells. In addition, single-cell studies described differences between primary and secondary senescent end-points, which have thus far not been considered functionally distinct. Here we discuss emerging concepts in senescence transmission and heterogeneity in primary and secondary senescence on a cellular and organ level. Springer International Publishing 2020-09-16 2021 /pmc/articles/PMC7897614/ /pubmed/32936311 http://dx.doi.org/10.1007/s00018-020-03638-0 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Review Rattanavirotkul, Nattaphong Kirschner, Kristina Chandra, Tamir Induction and transmission of oncogene-induced senescence |
title | Induction and transmission of oncogene-induced senescence |
title_full | Induction and transmission of oncogene-induced senescence |
title_fullStr | Induction and transmission of oncogene-induced senescence |
title_full_unstemmed | Induction and transmission of oncogene-induced senescence |
title_short | Induction and transmission of oncogene-induced senescence |
title_sort | induction and transmission of oncogene-induced senescence |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897614/ https://www.ncbi.nlm.nih.gov/pubmed/32936311 http://dx.doi.org/10.1007/s00018-020-03638-0 |
work_keys_str_mv | AT rattanavirotkulnattaphong inductionandtransmissionofoncogeneinducedsenescence AT kirschnerkristina inductionandtransmissionofoncogeneinducedsenescence AT chandratamir inductionandtransmissionofoncogeneinducedsenescence |