Prevention of age-associated neuronal hyperexcitability with improved learning and attention upon knockout or antagonism of LPAR2

Recent studies suggest that synaptic lysophosphatidic acids (LPAs) augment glutamate-dependent cortical excitability and sensory information processing in mice and humans via presynaptic LPAR2 activation. Here, we studied the consequences of LPAR2 deletion or antagonism on various aspects of cogniti...

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Detalles Bibliográficos
Autores principales: Fischer, Caroline, Endle, Heiko, Schumann, Lana, Wilken-Schmitz, Annett, Kaiser, Julia, Gerber, Susanne, Vogelaar, Christina F., Schmidt, Mirko H. H., Nitsch, Robert, Snodgrass, Isabel, Thomas, Dominique, Vogt, Johannes, Tegeder, Irmgard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897625/
https://www.ncbi.nlm.nih.gov/pubmed/32468095
http://dx.doi.org/10.1007/s00018-020-03553-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897625/
https://www.ncbi.nlm.nih.gov/pubmed/32468095
http://dx.doi.org/10.1007/s00018-020-03553-4

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