Immune Microenvironment: New Insight for Familial Adenomatous Polyposis

Currently, the main treatment for familial adenomatous polyposis (FAP) is surgery, however, surgery is far from ideal as there are many complications such as uncontrollable bowel movements, pouch inflammation, anastomotic stricture, and secondary fibroids. Therefore, it is necessary to further expan...

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Detalles Bibliográficos
Autores principales: Yang, Jun, Wen, Zhengqi, Li, Wenliang, Sun, Xianghua, Ma, Junrui, She, Xueke, Zhang, Hongbin, Tu, Changling, Wang, Guoqiang, Huang, Depei, Shen, Xudong, Dong, Jian, Zhang, Hushan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897671/
https://www.ncbi.nlm.nih.gov/pubmed/33628741
http://dx.doi.org/10.3389/fonc.2021.570241
Descripción
Sumario:Currently, the main treatment for familial adenomatous polyposis (FAP) is surgery, however, surgery is far from ideal as there are many complications such as uncontrollable bowel movements, pouch inflammation, anastomotic stricture, and secondary fibroids. Therefore, it is necessary to further expand the understanding of FAP and develop new treatments for FAP. The immune microenvironment including immune cells and cytokines, plays an important role in FAP and the progression of FAP to adenocarcinoma, thus it may be a promising treatment for FAP. In the current review, we summarized the recent progress in the immune microenvironment of FAP.

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