Immune Microenvironment: New Insight for Familial Adenomatous Polyposis

Currently, the main treatment for familial adenomatous polyposis (FAP) is surgery, however, surgery is far from ideal as there are many complications such as uncontrollable bowel movements, pouch inflammation, anastomotic stricture, and secondary fibroids. Therefore, it is necessary to further expan...

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Autores principales: Yang, Jun, Wen, Zhengqi, Li, Wenliang, Sun, Xianghua, Ma, Junrui, She, Xueke, Zhang, Hongbin, Tu, Changling, Wang, Guoqiang, Huang, Depei, Shen, Xudong, Dong, Jian, Zhang, Hushan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897671/
https://www.ncbi.nlm.nih.gov/pubmed/33628741
http://dx.doi.org/10.3389/fonc.2021.570241
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author Yang, Jun
Wen, Zhengqi
Li, Wenliang
Sun, Xianghua
Ma, Junrui
She, Xueke
Zhang, Hongbin
Tu, Changling
Wang, Guoqiang
Huang, Depei
Shen, Xudong
Dong, Jian
Zhang, Hushan
author_facet Yang, Jun
Wen, Zhengqi
Li, Wenliang
Sun, Xianghua
Ma, Junrui
She, Xueke
Zhang, Hongbin
Tu, Changling
Wang, Guoqiang
Huang, Depei
Shen, Xudong
Dong, Jian
Zhang, Hushan
author_sort Yang, Jun
collection PubMed
description Currently, the main treatment for familial adenomatous polyposis (FAP) is surgery, however, surgery is far from ideal as there are many complications such as uncontrollable bowel movements, pouch inflammation, anastomotic stricture, and secondary fibroids. Therefore, it is necessary to further expand the understanding of FAP and develop new treatments for FAP. The immune microenvironment including immune cells and cytokines, plays an important role in FAP and the progression of FAP to adenocarcinoma, thus it may be a promising treatment for FAP. In the current review, we summarized the recent progress in the immune microenvironment of FAP.
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spelling pubmed-78976712021-02-23 Immune Microenvironment: New Insight for Familial Adenomatous Polyposis Yang, Jun Wen, Zhengqi Li, Wenliang Sun, Xianghua Ma, Junrui She, Xueke Zhang, Hongbin Tu, Changling Wang, Guoqiang Huang, Depei Shen, Xudong Dong, Jian Zhang, Hushan Front Oncol Oncology Currently, the main treatment for familial adenomatous polyposis (FAP) is surgery, however, surgery is far from ideal as there are many complications such as uncontrollable bowel movements, pouch inflammation, anastomotic stricture, and secondary fibroids. Therefore, it is necessary to further expand the understanding of FAP and develop new treatments for FAP. The immune microenvironment including immune cells and cytokines, plays an important role in FAP and the progression of FAP to adenocarcinoma, thus it may be a promising treatment for FAP. In the current review, we summarized the recent progress in the immune microenvironment of FAP. Frontiers Media S.A. 2021-02-08 /pmc/articles/PMC7897671/ /pubmed/33628741 http://dx.doi.org/10.3389/fonc.2021.570241 Text en Copyright © 2021 Yang, Wen, Li, Sun, Ma, She, Zhang, Tu, Wang, Huang, Shen, Dong and Zhang http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Yang, Jun
Wen, Zhengqi
Li, Wenliang
Sun, Xianghua
Ma, Junrui
She, Xueke
Zhang, Hongbin
Tu, Changling
Wang, Guoqiang
Huang, Depei
Shen, Xudong
Dong, Jian
Zhang, Hushan
Immune Microenvironment: New Insight for Familial Adenomatous Polyposis
title Immune Microenvironment: New Insight for Familial Adenomatous Polyposis
title_full Immune Microenvironment: New Insight for Familial Adenomatous Polyposis
title_fullStr Immune Microenvironment: New Insight for Familial Adenomatous Polyposis
title_full_unstemmed Immune Microenvironment: New Insight for Familial Adenomatous Polyposis
title_short Immune Microenvironment: New Insight for Familial Adenomatous Polyposis
title_sort immune microenvironment: new insight for familial adenomatous polyposis
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897671/
https://www.ncbi.nlm.nih.gov/pubmed/33628741
http://dx.doi.org/10.3389/fonc.2021.570241
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