Prediction of neo-epitope immunogenicity reveals TCR recognition determinants and provides insight into immunoediting

CD8+ T cell recognition of peptide epitopes plays a central role in immune responses against pathogens and tumors. However, the rules that govern which peptides are truly recognized by existing T cell receptors (TCRs) remain poorly understood, precluding accurate predictions of neo-epitopes for canc...

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Detalles Bibliográficos
Autores principales: Schmidt, Julien, Smith, Angela R., Magnin, Morgane, Racle, Julien, Devlin, Jason R., Bobisse, Sara, Cesbron, Julien, Bonnet, Victor, Carmona, Santiago J., Huber, Florian, Ciriello, Giovanni, Speiser, Daniel E., Bassani-Sternberg, Michal, Coukos, George, Baker, Brian M., Harari, Alexandre, Gfeller, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897774/
https://www.ncbi.nlm.nih.gov/pubmed/33665637
http://dx.doi.org/10.1016/j.xcrm.2021.100194

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