A standard calculation methodology for human doubly labeled water studies

The doubly labeled water (DLW) method measures total energy expenditure (TEE) in free-living subjects. Several equations are used to convert isotopic data into TEE. Using the International Atomic Energy Agency (IAEA) DLW database (5,756 measurements of adults and children), we show considerable vari...

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Detalles Bibliográficos
Autores principales: Speakman, John R., Yamada, Yosuke, Sagayama, Hiroyuki, Berman, Elena S.F., Ainslie, Philip N., Andersen, Lene F., Anderson, Liam J., Arab, Lenore, Baddou, Issaad, Bedu-Addo, Kweku, Blaak, Ellen E., Blanc, Stephane, Bonomi, Alberto G., Bouten, Carlijn V.C., Bovet, Pascal, Buchowski, Maciej S., Butte, Nancy F., Camps, Stefan G.J.A., Close, Graeme L., Cooper, Jamie A., Creasy, Seth A., Das, Sai Krupa, Cooper, Richard, Dugas, Lara R., Ebbeling, Cara B., Ekelund, Ulf, Entringer, Sonja, Forrester, Terrence, Fudge, Barry W., Goris, Annelies H., Gurven, Michael, Hambly, Catherine, El Hamdouchi, Asmaa, Hoos, Marije B., Hu, Sumei, Joonas, Noorjehan, Joosen, Annemiek M., Katzmarzyk, Peter, Kempen, Kitty P., Kimura, Misaka, Kraus, William E., Kushner, Robert F., Lambert, Estelle V., Leonard, William R., Lessan, Nader, Ludwig, David S., Martin, Corby K., Medin, Anine C., Meijer, Erwin P., Morehen, James C., Morton, James P., Neuhouser, Marian L., Nicklas, Theresa A., Ojiambo, Robert M., Pietiläinen, Kirsi H., Pitsiladis, Yannis P., Plange-Rhule, Jacob, Plasqui, Guy, Prentice, Ross L., Rabinovich, Roberto A., Racette, Susan B., Raichlen, David A., Ravussin, Eric, Reynolds, Rebecca M., Roberts, Susan B., Schuit, Albertine J., Sjödin, Anders M., Stice, Eric, Urlacher, Samuel S., Valenti, Giulio, Van Etten, Ludo M., Van Mil, Edgar A., Wells, Jonathan C.K., Wilson, George, Wood, Brian M., Yanovski, Jack, Yoshida, Tsukasa, Zhang, Xueying, Murphy-Alford, Alexia J., Loechl, Cornelia U., Melanson, Edward L., Luke, Amy H., Pontzer, Herman, Rood, Jennifer, Schoeller, Dale A., Westerterp, Klaas R., Wong, William W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897799/
https://www.ncbi.nlm.nih.gov/pubmed/33665639
http://dx.doi.org/10.1016/j.xcrm.2021.100203
Descripción
Sumario:The doubly labeled water (DLW) method measures total energy expenditure (TEE) in free-living subjects. Several equations are used to convert isotopic data into TEE. Using the International Atomic Energy Agency (IAEA) DLW database (5,756 measurements of adults and children), we show considerable variability is introduced by different equations. The estimated rCO(2) is sensitive to the dilution space ratio (DSR) of the two isotopes. Based on performance in validation studies, we propose a new equation based on a new estimate of the mean DSR. The DSR is lower at low body masses (<10 kg). Using data for 1,021 babies and infants, we show that the DSR varies non-linearly with body mass between 0 and 10 kg. Using this relationship to predict DSR from weight provides an equation for rCO(2) over this size range that agrees well with indirect calorimetry (average difference 0.64%; SD = 12.2%). We propose adoption of these equations in future studies.

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