Cargando…
Single-cell analysis shows that adipose tissue of persons with both HIV and diabetes is enriched for clonal, cytotoxic, and CMV-specific CD4+ T cells
Persons with HIV are at increased risk for diabetes mellitus compared with individuals without HIV. Adipose tissue is an important regulator of glucose and lipid metabolism, and adipose tissue T cells modulate local inflammatory responses and, by extension, adipocyte function. Persons with HIV and d...
Autores principales: | Wanjalla, Celestine N., McDonnell, Wyatt J., Ram, Ramesh, Chopra, Abha, Gangula, Rama, Leary, Shay, Mashayekhi, Mona, Simmons, Joshua D., Warren, Christian M., Bailin, Samuel, Gabriel, Curtis L., Guo, Liang, Furch, Briana D., Lima, Morgan C., Woodward, Beverly O., Hannah, LaToya, Pilkinton, Mark A., Fuller, Daniela T., Kawai, Kenji, Virmani, Renu, Finn, Aloke V., Hasty, Alyssa H., Mallal, Simon A., Kalams, Spyros A., Koethe, John R. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897802/ https://www.ncbi.nlm.nih.gov/pubmed/33665640 http://dx.doi.org/10.1016/j.xcrm.2021.100205 |
Ejemplares similares
-
Changes in subcutaneous white adipose tissue cellular composition and molecular programs underlie glucose intolerance in persons with HIV
por: Bailin, Samuel S., et al.
Publicado: (2023) -
Adipose Tissue in Persons With HIV Is Enriched for CD4(+) T Effector Memory and T Effector Memory RA(+) Cells, Which Show Higher CD69 Expression and CD57, CX3CR1, GPR56 Co-expression With Increasing Glucose Intolerance
por: Wanjalla, Celestine N., et al.
Publicado: (2019) -
Leptin Promotes Greater Ki67 Expression in CD4(+) T Cells From Obese Compared to Lean Persons Living With HIV
por: Fuseini, Hubaida, et al.
Publicado: (2022) -
SUN-544 Immunologic Effects of GLP-1 Activation in Obese Adipose Tissue
por: Mashayekhi, Mona, et al.
Publicado: (2020) -
The Contribution of Arachidonic Acid Metabolites EETs to Inflammation in Obesity
por: Mashayekhi, Mona, et al.
Publicado: (2021)