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Mistaken administration of a repeat loading dose of Degarelix leading to acute psychosis
Advanced and metastatic prostate cancer is often managed with hormonal blockage. Luteinising hormone-releasing hormone antagonists achieve rapid testosterone suppression and are used for the treatment of advanced or metastatic prostate cancer. Degarelix is a luteinising hormone-releasing hormone ant...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897814/ https://www.ncbi.nlm.nih.gov/pubmed/33680481 http://dx.doi.org/10.1177/2054270420983105 |
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author | Hamdoon, Musaab Satchi, Maria Fawke, Fay Madaan, Sanjeev |
author_facet | Hamdoon, Musaab Satchi, Maria Fawke, Fay Madaan, Sanjeev |
author_sort | Hamdoon, Musaab |
collection | PubMed |
description | Advanced and metastatic prostate cancer is often managed with hormonal blockage. Luteinising hormone-releasing hormone antagonists achieve rapid testosterone suppression and are used for the treatment of advanced or metastatic prostate cancer. Degarelix is a luteinising hormone-releasing hormone antagonist and is given as a loading dose, followed by a monthly maintenance dose. We report a case where a patient was inadvertently given a second loading dose of Degarelix that resulted in acute psychosis in the form of panic attacks, delusions, suicidal thoughts, insomnia and some visual hallucinations, which are not reported as side-effects of Degarelix. |
format | Online Article Text |
id | pubmed-7897814 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-78978142021-03-04 Mistaken administration of a repeat loading dose of Degarelix leading to acute psychosis Hamdoon, Musaab Satchi, Maria Fawke, Fay Madaan, Sanjeev JRSM Open Case Report Advanced and metastatic prostate cancer is often managed with hormonal blockage. Luteinising hormone-releasing hormone antagonists achieve rapid testosterone suppression and are used for the treatment of advanced or metastatic prostate cancer. Degarelix is a luteinising hormone-releasing hormone antagonist and is given as a loading dose, followed by a monthly maintenance dose. We report a case where a patient was inadvertently given a second loading dose of Degarelix that resulted in acute psychosis in the form of panic attacks, delusions, suicidal thoughts, insomnia and some visual hallucinations, which are not reported as side-effects of Degarelix. SAGE Publications 2021-02-19 /pmc/articles/PMC7897814/ /pubmed/33680481 http://dx.doi.org/10.1177/2054270420983105 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Case Report Hamdoon, Musaab Satchi, Maria Fawke, Fay Madaan, Sanjeev Mistaken administration of a repeat loading dose of Degarelix leading to acute psychosis |
title | Mistaken administration of a repeat loading dose of Degarelix leading to acute psychosis |
title_full | Mistaken administration of a repeat loading dose of Degarelix leading to acute psychosis |
title_fullStr | Mistaken administration of a repeat loading dose of Degarelix leading to acute psychosis |
title_full_unstemmed | Mistaken administration of a repeat loading dose of Degarelix leading to acute psychosis |
title_short | Mistaken administration of a repeat loading dose of Degarelix leading to acute psychosis |
title_sort | mistaken administration of a repeat loading dose of degarelix leading to acute psychosis |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897814/ https://www.ncbi.nlm.nih.gov/pubmed/33680481 http://dx.doi.org/10.1177/2054270420983105 |
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