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Lung adenocarcinoma and sequential antineutrophil cytoplasmic antibody-associated vasculitis: a case report

The relationship between antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and lung cancer remains unclear. A 66-year-old man presented with pulmonary nodules. Histological examination of a specimen from computed tomography-guided percutaneous transthoracic biopsy revealed adeno...

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Autores principales: Zhang, Chun-Yang, Miao, Ran, Li, Wei, Ning, Hao-Yong, Meng, Xiang-En, Han, Zhi-Hai, Qin, Feng, Liang, Ying-Kui, Li, Ming-Xv
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897826/
https://www.ncbi.nlm.nih.gov/pubmed/33596705
http://dx.doi.org/10.1177/0300060521993319
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author Zhang, Chun-Yang
Miao, Ran
Li, Wei
Ning, Hao-Yong
Meng, Xiang-En
Han, Zhi-Hai
Qin, Feng
Liang, Ying-Kui
Li, Ming-Xv
author_facet Zhang, Chun-Yang
Miao, Ran
Li, Wei
Ning, Hao-Yong
Meng, Xiang-En
Han, Zhi-Hai
Qin, Feng
Liang, Ying-Kui
Li, Ming-Xv
author_sort Zhang, Chun-Yang
collection PubMed
description The relationship between antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and lung cancer remains unclear. A 66-year-old man presented with pulmonary nodules. Histological examination of a specimen from computed tomography-guided percutaneous transthoracic biopsy revealed adenocarcinoma. The patient was treated using cryoablation and systemic chemotherapy. Sixteen months later, the patient presented with fever, nasal inflammation, recurrent lung lesions, elevated serum creatinine levels, and high levels of ANCA. Histological examination of a specimen from ultrasound-guided percutaneous renal biopsy revealed pauci-immune necrotizing crescentic glomerulonephritis. The patient responded to treatment, but granulomatosis with polyangiitis recurred and he later died. This case highlights the possibility of sequential AAV with lung cancer. Although this is relatively rare, further research is needed to better understand the association or pathophysiological link between lung cancer and AAV.
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spelling pubmed-78978262021-03-04 Lung adenocarcinoma and sequential antineutrophil cytoplasmic antibody-associated vasculitis: a case report Zhang, Chun-Yang Miao, Ran Li, Wei Ning, Hao-Yong Meng, Xiang-En Han, Zhi-Hai Qin, Feng Liang, Ying-Kui Li, Ming-Xv J Int Med Res Case Report The relationship between antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and lung cancer remains unclear. A 66-year-old man presented with pulmonary nodules. Histological examination of a specimen from computed tomography-guided percutaneous transthoracic biopsy revealed adenocarcinoma. The patient was treated using cryoablation and systemic chemotherapy. Sixteen months later, the patient presented with fever, nasal inflammation, recurrent lung lesions, elevated serum creatinine levels, and high levels of ANCA. Histological examination of a specimen from ultrasound-guided percutaneous renal biopsy revealed pauci-immune necrotizing crescentic glomerulonephritis. The patient responded to treatment, but granulomatosis with polyangiitis recurred and he later died. This case highlights the possibility of sequential AAV with lung cancer. Although this is relatively rare, further research is needed to better understand the association or pathophysiological link between lung cancer and AAV. SAGE Publications 2021-02-17 /pmc/articles/PMC7897826/ /pubmed/33596705 http://dx.doi.org/10.1177/0300060521993319 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Zhang, Chun-Yang
Miao, Ran
Li, Wei
Ning, Hao-Yong
Meng, Xiang-En
Han, Zhi-Hai
Qin, Feng
Liang, Ying-Kui
Li, Ming-Xv
Lung adenocarcinoma and sequential antineutrophil cytoplasmic antibody-associated vasculitis: a case report
title Lung adenocarcinoma and sequential antineutrophil cytoplasmic antibody-associated vasculitis: a case report
title_full Lung adenocarcinoma and sequential antineutrophil cytoplasmic antibody-associated vasculitis: a case report
title_fullStr Lung adenocarcinoma and sequential antineutrophil cytoplasmic antibody-associated vasculitis: a case report
title_full_unstemmed Lung adenocarcinoma and sequential antineutrophil cytoplasmic antibody-associated vasculitis: a case report
title_short Lung adenocarcinoma and sequential antineutrophil cytoplasmic antibody-associated vasculitis: a case report
title_sort lung adenocarcinoma and sequential antineutrophil cytoplasmic antibody-associated vasculitis: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897826/
https://www.ncbi.nlm.nih.gov/pubmed/33596705
http://dx.doi.org/10.1177/0300060521993319
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