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Genome sequencing of a novel variant of fowl adenovirus B reveals mosaicism in the pattern of homologous recombination events

We determined the genomic sequence of a Ukrainian strain of fowl adenovirus B (FAdV-B). The isolate (D2453/1) shared 97.2% to 98.4% nucleotide sequence identity with other viruses belonging to the species Fowl aviadenovirus B. Marked genetic divergence was seen in the hexon, fiber, and ORF19 genes,...

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Autores principales: Homonnay, Zalán, Jakab, Szilvia, Bali, Krisztina, Kaszab, Eszter, Mató, Tamás, Kiss, István, Palya, Vilmos, Bányai, Krisztián
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897897/
https://www.ncbi.nlm.nih.gov/pubmed/33616725
http://dx.doi.org/10.1007/s00705-021-04972-9
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author Homonnay, Zalán
Jakab, Szilvia
Bali, Krisztina
Kaszab, Eszter
Mató, Tamás
Kiss, István
Palya, Vilmos
Bányai, Krisztián
author_facet Homonnay, Zalán
Jakab, Szilvia
Bali, Krisztina
Kaszab, Eszter
Mató, Tamás
Kiss, István
Palya, Vilmos
Bányai, Krisztián
author_sort Homonnay, Zalán
collection PubMed
description We determined the genomic sequence of a Ukrainian strain of fowl adenovirus B (FAdV-B). The isolate (D2453/1) shared 97.2% to 98.4% nucleotide sequence identity with other viruses belonging to the species Fowl aviadenovirus B. Marked genetic divergence was seen in the hexon, fiber, and ORF19 genes, and phylogenetic analysis suggested that recombination events had occurred in these regions. Our analysis revealed mosaicism in the recombination patterns, a finding that has also been described in the genomes of strains of FAdV-D and FAdV-E. The shared recombination breakpoints, affecting the same genomic regions in viruses belonging to different species, suggest that similar selection mechanisms are acting on the key neutralization antigens and epitopes in viruses of different FAdV species. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00705-021-04972-9.
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spelling pubmed-78978972021-02-22 Genome sequencing of a novel variant of fowl adenovirus B reveals mosaicism in the pattern of homologous recombination events Homonnay, Zalán Jakab, Szilvia Bali, Krisztina Kaszab, Eszter Mató, Tamás Kiss, István Palya, Vilmos Bányai, Krisztián Arch Virol Annotated Sequence Record We determined the genomic sequence of a Ukrainian strain of fowl adenovirus B (FAdV-B). The isolate (D2453/1) shared 97.2% to 98.4% nucleotide sequence identity with other viruses belonging to the species Fowl aviadenovirus B. Marked genetic divergence was seen in the hexon, fiber, and ORF19 genes, and phylogenetic analysis suggested that recombination events had occurred in these regions. Our analysis revealed mosaicism in the recombination patterns, a finding that has also been described in the genomes of strains of FAdV-D and FAdV-E. The shared recombination breakpoints, affecting the same genomic regions in viruses belonging to different species, suggest that similar selection mechanisms are acting on the key neutralization antigens and epitopes in viruses of different FAdV species. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00705-021-04972-9. Springer Vienna 2021-02-22 2021 /pmc/articles/PMC7897897/ /pubmed/33616725 http://dx.doi.org/10.1007/s00705-021-04972-9 Text en © The Author(s), under exclusive licence to Springer-Verlag GmbH, AT part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Annotated Sequence Record
Homonnay, Zalán
Jakab, Szilvia
Bali, Krisztina
Kaszab, Eszter
Mató, Tamás
Kiss, István
Palya, Vilmos
Bányai, Krisztián
Genome sequencing of a novel variant of fowl adenovirus B reveals mosaicism in the pattern of homologous recombination events
title Genome sequencing of a novel variant of fowl adenovirus B reveals mosaicism in the pattern of homologous recombination events
title_full Genome sequencing of a novel variant of fowl adenovirus B reveals mosaicism in the pattern of homologous recombination events
title_fullStr Genome sequencing of a novel variant of fowl adenovirus B reveals mosaicism in the pattern of homologous recombination events
title_full_unstemmed Genome sequencing of a novel variant of fowl adenovirus B reveals mosaicism in the pattern of homologous recombination events
title_short Genome sequencing of a novel variant of fowl adenovirus B reveals mosaicism in the pattern of homologous recombination events
title_sort genome sequencing of a novel variant of fowl adenovirus b reveals mosaicism in the pattern of homologous recombination events
topic Annotated Sequence Record
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897897/
https://www.ncbi.nlm.nih.gov/pubmed/33616725
http://dx.doi.org/10.1007/s00705-021-04972-9
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