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Genome sequencing of a novel variant of fowl adenovirus B reveals mosaicism in the pattern of homologous recombination events
We determined the genomic sequence of a Ukrainian strain of fowl adenovirus B (FAdV-B). The isolate (D2453/1) shared 97.2% to 98.4% nucleotide sequence identity with other viruses belonging to the species Fowl aviadenovirus B. Marked genetic divergence was seen in the hexon, fiber, and ORF19 genes,...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Vienna
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897897/ https://www.ncbi.nlm.nih.gov/pubmed/33616725 http://dx.doi.org/10.1007/s00705-021-04972-9 |
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author | Homonnay, Zalán Jakab, Szilvia Bali, Krisztina Kaszab, Eszter Mató, Tamás Kiss, István Palya, Vilmos Bányai, Krisztián |
author_facet | Homonnay, Zalán Jakab, Szilvia Bali, Krisztina Kaszab, Eszter Mató, Tamás Kiss, István Palya, Vilmos Bányai, Krisztián |
author_sort | Homonnay, Zalán |
collection | PubMed |
description | We determined the genomic sequence of a Ukrainian strain of fowl adenovirus B (FAdV-B). The isolate (D2453/1) shared 97.2% to 98.4% nucleotide sequence identity with other viruses belonging to the species Fowl aviadenovirus B. Marked genetic divergence was seen in the hexon, fiber, and ORF19 genes, and phylogenetic analysis suggested that recombination events had occurred in these regions. Our analysis revealed mosaicism in the recombination patterns, a finding that has also been described in the genomes of strains of FAdV-D and FAdV-E. The shared recombination breakpoints, affecting the same genomic regions in viruses belonging to different species, suggest that similar selection mechanisms are acting on the key neutralization antigens and epitopes in viruses of different FAdV species. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00705-021-04972-9. |
format | Online Article Text |
id | pubmed-7897897 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Vienna |
record_format | MEDLINE/PubMed |
spelling | pubmed-78978972021-02-22 Genome sequencing of a novel variant of fowl adenovirus B reveals mosaicism in the pattern of homologous recombination events Homonnay, Zalán Jakab, Szilvia Bali, Krisztina Kaszab, Eszter Mató, Tamás Kiss, István Palya, Vilmos Bányai, Krisztián Arch Virol Annotated Sequence Record We determined the genomic sequence of a Ukrainian strain of fowl adenovirus B (FAdV-B). The isolate (D2453/1) shared 97.2% to 98.4% nucleotide sequence identity with other viruses belonging to the species Fowl aviadenovirus B. Marked genetic divergence was seen in the hexon, fiber, and ORF19 genes, and phylogenetic analysis suggested that recombination events had occurred in these regions. Our analysis revealed mosaicism in the recombination patterns, a finding that has also been described in the genomes of strains of FAdV-D and FAdV-E. The shared recombination breakpoints, affecting the same genomic regions in viruses belonging to different species, suggest that similar selection mechanisms are acting on the key neutralization antigens and epitopes in viruses of different FAdV species. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00705-021-04972-9. Springer Vienna 2021-02-22 2021 /pmc/articles/PMC7897897/ /pubmed/33616725 http://dx.doi.org/10.1007/s00705-021-04972-9 Text en © The Author(s), under exclusive licence to Springer-Verlag GmbH, AT part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Annotated Sequence Record Homonnay, Zalán Jakab, Szilvia Bali, Krisztina Kaszab, Eszter Mató, Tamás Kiss, István Palya, Vilmos Bányai, Krisztián Genome sequencing of a novel variant of fowl adenovirus B reveals mosaicism in the pattern of homologous recombination events |
title | Genome sequencing of a novel variant of fowl adenovirus B reveals mosaicism in the pattern of homologous recombination events |
title_full | Genome sequencing of a novel variant of fowl adenovirus B reveals mosaicism in the pattern of homologous recombination events |
title_fullStr | Genome sequencing of a novel variant of fowl adenovirus B reveals mosaicism in the pattern of homologous recombination events |
title_full_unstemmed | Genome sequencing of a novel variant of fowl adenovirus B reveals mosaicism in the pattern of homologous recombination events |
title_short | Genome sequencing of a novel variant of fowl adenovirus B reveals mosaicism in the pattern of homologous recombination events |
title_sort | genome sequencing of a novel variant of fowl adenovirus b reveals mosaicism in the pattern of homologous recombination events |
topic | Annotated Sequence Record |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897897/ https://www.ncbi.nlm.nih.gov/pubmed/33616725 http://dx.doi.org/10.1007/s00705-021-04972-9 |
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