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JF1/B6F1 Ngly1(−/−) mouse as an isogenic animal model of NGLY1 deficiency

N-Glycanase 1 (NGLY1) deficiency is a congenital disorder caused by mutations in the NGLY1 gene. Because systemic Ngly1(−/−) mice with a C57BL/6 (B6) background are embryonically lethal, studies on the mechanism of NGLY1 deficiency using mice have been problematic. In this study, B6-Ngly1(−/+) mice...

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Detalles Bibliográficos
Autores principales:	ASAHINA, Makoto, FUJINAWA, Reiko, FUJIHIRA, Haruhiko, MASAHARA-NEGISHI, Yuki, ANDOU, Tomohiro, TOZAWA, Ryuichi, SUZUKI, Tadashi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Japan Academy 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897899/ https://www.ncbi.nlm.nih.gov/pubmed/33563880 http://dx.doi.org/10.2183/pjab.97.005

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