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Correlations between glycolysis with clinical traits and immune function in bladder urothelial carcinoma

Background: Glycolysis was a representative hallmark in the tumor microenvironment (TME), and we aimed to explore the correlations between glycolysis with immune activity and clinical traits in bladder urothelial carcinoma (BLCA). Methods: Our study obtained glycolysis scores for each BLCA samples f...

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Autores principales: Che, Kai, Han, Wenkai, Li, Danxia, Cui, Shuxia, Zhang, Mingxin, Yang, Xiaokun, Niu, Haitao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897921/
https://www.ncbi.nlm.nih.gov/pubmed/33558879
http://dx.doi.org/10.1042/BSR20203982
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author Che, Kai
Han, Wenkai
Li, Danxia
Cui, Shuxia
Zhang, Mingxin
Yang, Xiaokun
Niu, Haitao
author_facet Che, Kai
Han, Wenkai
Li, Danxia
Cui, Shuxia
Zhang, Mingxin
Yang, Xiaokun
Niu, Haitao
author_sort Che, Kai
collection PubMed
description Background: Glycolysis was a representative hallmark in the tumor microenvironment (TME), and we aimed to explore the correlations between glycolysis with immune activity and clinical traits in bladder urothelial carcinoma (BLCA). Methods: Our study obtained glycolysis scores for each BLCA samples from TCGA by a single-sample gene set enrichment analysis (ssGSEA) algorithm, based on a glycolytic gene set. The relationship between glycolysis with prognosis, clinical characteristics, and immune function were investigated subsequently. Results: We found that enhanced glycolysis was associated with poor prognosis and metastasis in BLCA. Moreover, glycolysis had a close correlation with immune function, and enhanced glycolysis increased immune activities. In other words, glycolysis had a positive correlation with immune activities. Immune checkpoints such as IDO1, CD274, were up-regulated in high-glycolysis group as well. Conclusion: We speculated that in BLCA, elevated glycolysis enhanced immune function, which caused tumor cells to overexpress immune checkpoints to evade immune surveillance. Inhibition of glycolysis might be a promising assistant for immunotherapy in bladder cancer.
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spelling pubmed-78979212021-02-25 Correlations between glycolysis with clinical traits and immune function in bladder urothelial carcinoma Che, Kai Han, Wenkai Li, Danxia Cui, Shuxia Zhang, Mingxin Yang, Xiaokun Niu, Haitao Biosci Rep Bioinformatics Background: Glycolysis was a representative hallmark in the tumor microenvironment (TME), and we aimed to explore the correlations between glycolysis with immune activity and clinical traits in bladder urothelial carcinoma (BLCA). Methods: Our study obtained glycolysis scores for each BLCA samples from TCGA by a single-sample gene set enrichment analysis (ssGSEA) algorithm, based on a glycolytic gene set. The relationship between glycolysis with prognosis, clinical characteristics, and immune function were investigated subsequently. Results: We found that enhanced glycolysis was associated with poor prognosis and metastasis in BLCA. Moreover, glycolysis had a close correlation with immune function, and enhanced glycolysis increased immune activities. In other words, glycolysis had a positive correlation with immune activities. Immune checkpoints such as IDO1, CD274, were up-regulated in high-glycolysis group as well. Conclusion: We speculated that in BLCA, elevated glycolysis enhanced immune function, which caused tumor cells to overexpress immune checkpoints to evade immune surveillance. Inhibition of glycolysis might be a promising assistant for immunotherapy in bladder cancer. Portland Press Ltd. 2021-02-19 /pmc/articles/PMC7897921/ /pubmed/33558879 http://dx.doi.org/10.1042/BSR20203982 Text en © 2021 The Author(s). https://creativecommons.org/licenses/by/4.0/ This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Bioinformatics
Che, Kai
Han, Wenkai
Li, Danxia
Cui, Shuxia
Zhang, Mingxin
Yang, Xiaokun
Niu, Haitao
Correlations between glycolysis with clinical traits and immune function in bladder urothelial carcinoma
title Correlations between glycolysis with clinical traits and immune function in bladder urothelial carcinoma
title_full Correlations between glycolysis with clinical traits and immune function in bladder urothelial carcinoma
title_fullStr Correlations between glycolysis with clinical traits and immune function in bladder urothelial carcinoma
title_full_unstemmed Correlations between glycolysis with clinical traits and immune function in bladder urothelial carcinoma
title_short Correlations between glycolysis with clinical traits and immune function in bladder urothelial carcinoma
title_sort correlations between glycolysis with clinical traits and immune function in bladder urothelial carcinoma
topic Bioinformatics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897921/
https://www.ncbi.nlm.nih.gov/pubmed/33558879
http://dx.doi.org/10.1042/BSR20203982
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