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Correlations between glycolysis with clinical traits and immune function in bladder urothelial carcinoma
Background: Glycolysis was a representative hallmark in the tumor microenvironment (TME), and we aimed to explore the correlations between glycolysis with immune activity and clinical traits in bladder urothelial carcinoma (BLCA). Methods: Our study obtained glycolysis scores for each BLCA samples f...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897921/ https://www.ncbi.nlm.nih.gov/pubmed/33558879 http://dx.doi.org/10.1042/BSR20203982 |
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author | Che, Kai Han, Wenkai Li, Danxia Cui, Shuxia Zhang, Mingxin Yang, Xiaokun Niu, Haitao |
author_facet | Che, Kai Han, Wenkai Li, Danxia Cui, Shuxia Zhang, Mingxin Yang, Xiaokun Niu, Haitao |
author_sort | Che, Kai |
collection | PubMed |
description | Background: Glycolysis was a representative hallmark in the tumor microenvironment (TME), and we aimed to explore the correlations between glycolysis with immune activity and clinical traits in bladder urothelial carcinoma (BLCA). Methods: Our study obtained glycolysis scores for each BLCA samples from TCGA by a single-sample gene set enrichment analysis (ssGSEA) algorithm, based on a glycolytic gene set. The relationship between glycolysis with prognosis, clinical characteristics, and immune function were investigated subsequently. Results: We found that enhanced glycolysis was associated with poor prognosis and metastasis in BLCA. Moreover, glycolysis had a close correlation with immune function, and enhanced glycolysis increased immune activities. In other words, glycolysis had a positive correlation with immune activities. Immune checkpoints such as IDO1, CD274, were up-regulated in high-glycolysis group as well. Conclusion: We speculated that in BLCA, elevated glycolysis enhanced immune function, which caused tumor cells to overexpress immune checkpoints to evade immune surveillance. Inhibition of glycolysis might be a promising assistant for immunotherapy in bladder cancer. |
format | Online Article Text |
id | pubmed-7897921 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78979212021-02-25 Correlations between glycolysis with clinical traits and immune function in bladder urothelial carcinoma Che, Kai Han, Wenkai Li, Danxia Cui, Shuxia Zhang, Mingxin Yang, Xiaokun Niu, Haitao Biosci Rep Bioinformatics Background: Glycolysis was a representative hallmark in the tumor microenvironment (TME), and we aimed to explore the correlations between glycolysis with immune activity and clinical traits in bladder urothelial carcinoma (BLCA). Methods: Our study obtained glycolysis scores for each BLCA samples from TCGA by a single-sample gene set enrichment analysis (ssGSEA) algorithm, based on a glycolytic gene set. The relationship between glycolysis with prognosis, clinical characteristics, and immune function were investigated subsequently. Results: We found that enhanced glycolysis was associated with poor prognosis and metastasis in BLCA. Moreover, glycolysis had a close correlation with immune function, and enhanced glycolysis increased immune activities. In other words, glycolysis had a positive correlation with immune activities. Immune checkpoints such as IDO1, CD274, were up-regulated in high-glycolysis group as well. Conclusion: We speculated that in BLCA, elevated glycolysis enhanced immune function, which caused tumor cells to overexpress immune checkpoints to evade immune surveillance. Inhibition of glycolysis might be a promising assistant for immunotherapy in bladder cancer. Portland Press Ltd. 2021-02-19 /pmc/articles/PMC7897921/ /pubmed/33558879 http://dx.doi.org/10.1042/BSR20203982 Text en © 2021 The Author(s). https://creativecommons.org/licenses/by/4.0/ This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Bioinformatics Che, Kai Han, Wenkai Li, Danxia Cui, Shuxia Zhang, Mingxin Yang, Xiaokun Niu, Haitao Correlations between glycolysis with clinical traits and immune function in bladder urothelial carcinoma |
title | Correlations between glycolysis with clinical traits and immune function in bladder urothelial carcinoma |
title_full | Correlations between glycolysis with clinical traits and immune function in bladder urothelial carcinoma |
title_fullStr | Correlations between glycolysis with clinical traits and immune function in bladder urothelial carcinoma |
title_full_unstemmed | Correlations between glycolysis with clinical traits and immune function in bladder urothelial carcinoma |
title_short | Correlations between glycolysis with clinical traits and immune function in bladder urothelial carcinoma |
title_sort | correlations between glycolysis with clinical traits and immune function in bladder urothelial carcinoma |
topic | Bioinformatics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897921/ https://www.ncbi.nlm.nih.gov/pubmed/33558879 http://dx.doi.org/10.1042/BSR20203982 |
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