Intestinal Phospholipid Disequilibrium Initiates an ER Stress Response That Drives Goblet Cell Necroptosis and Spontaneous Colitis in Mice

BACKGROUND & AIMS: Patients with ulcerative colitis have low concentrations of the major membrane lipid phosphatidylcholine (PC) in gastrointestinal mucus, suggesting that defects in colonic PC metabolism might be involved in the development of colitis. To determine the precise role that PC play...

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Detalles Bibliográficos
Autores principales: Kennelly, John P., Carlin, Stephanie, Ju, Tingting, van der Veen, Jelske N., Nelson, Randal C., Buteau, Jean, Thiesen, Aducio, Richard, Caroline, Willing, Ben P., Jacobs, René L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898069/
https://www.ncbi.nlm.nih.gov/pubmed/33238221
http://dx.doi.org/10.1016/j.jcmgh.2020.11.006

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