Cholangiopathy and Biliary Fibrosis in Cyp2c70-Deficient Mice Are Fully Reversed by Ursodeoxycholic Acid

BACKGROUND AND AIMS: Bile acids (BAs) aid intestinal fat absorption and exert systemic actions by receptor-mediated signaling. BA receptors have been identified as drug targets for liver diseases. Yet, differences in BA metabolism between humans and mice hamper translation of pre-clinical outcomes....

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Detalles Bibliográficos
Autores principales: de Boer, Jan Freark, de Vries, Hilde D., Palmiotti, Anna, Li, Rumei, Doestzada, Marwah, Hoogerland, Joanne A., Fu, Jingyuan, La Rose, Anouk M., Westerterp, Marit, Mulder, Niels L., Hovingh, Milaine V., Koehorst, Martijn, Kloosterhuis, Niels J., Wolters, Justina C., Bloks, Vincent W., Haas, Joel T., Dombrowicz, David, Staels, Bart, van de Sluis, Bart, Kuipers, Folkert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898074/
https://www.ncbi.nlm.nih.gov/pubmed/33309945
http://dx.doi.org/10.1016/j.jcmgh.2020.12.004

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