Cargando…

Clinical Characteristics and Short-Term Outcomes of Chronic Dialysis Patients Admitted for COVID-19 in Metro Manila, Philippines

AIM: Data published on COVID-19 in the Filipino population, particularly those with end stage kidney disease (ESKD) are still lacking. METHODS: We performed a retrospective, observational study of 68 ESKD patients admitted with COVID-19 infection at a tertiary hospital in Metro Manila, Philippines f...

Descripción completa

Detalles Bibliográficos
Autores principales: Tomacruz, Isabelle Dominique, So, Paolo Nikolai, Pasilan, Renz Michael, Camenforte, Jameel Kristine, Duavit, Maria Isabel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898205/
https://www.ncbi.nlm.nih.gov/pubmed/33628044
http://dx.doi.org/10.2147/IJNRD.S287455
_version_ 1783653817042075648
author Tomacruz, Isabelle Dominique
So, Paolo Nikolai
Pasilan, Renz Michael
Camenforte, Jameel Kristine
Duavit, Maria Isabel
author_facet Tomacruz, Isabelle Dominique
So, Paolo Nikolai
Pasilan, Renz Michael
Camenforte, Jameel Kristine
Duavit, Maria Isabel
author_sort Tomacruz, Isabelle Dominique
collection PubMed
description AIM: Data published on COVID-19 in the Filipino population, particularly those with end stage kidney disease (ESKD) are still lacking. METHODS: We performed a retrospective, observational study of 68 ESKD patients admitted with COVID-19 infection at a tertiary hospital in Metro Manila, Philippines from April 1, 2020 to July 31, 2020. We compared the clinical features, baseline laboratory data, treatment strategies and short-term outcomes between those who survived and those who died. We also determined the risk factors associated with mortality from COVID-19. RESULTS: Mean age was 54.5 years old, 66% were male. All patients admitted were on maintenance hemodialysis (HD). The most common presenting symptoms were dyspnea (57%), fever (47%) and cough (38%). There was an equal number of patients on high flow nasal cannula (17.7%) and invasive mechanical ventilation (17.7%). ICU admission was required in 17.7% of the cohort. In-hospital death occurred in 25% of the patients. Admission PaO(2)/FiO(2) (PF) ratios (162 ± 134 versus 356 ± 181; p=0.0009) were lower, and procalcitonin (6.07 ± 10.5ng/mL versus 0.73 ± 3.61 ng/mL; p=0.02), lactate dehydrogenase (396 ± 274U/L versus 282 ± 148 U/L; p=0.03), and white blood cell counts (10 ± 7.3 x 10(9)/L versus 6.3 ± 4.2 x 10(9)/L; p= 0.0039) were significantly higher among those who died compared to those who survived. After adjusting for confounders, only low PF ratio (HR 1.01 for every unit decrease, 95% CI 1–1.01) and need for ventilation (HR 6.45, 95% CI 1.16–35.97) conferred a significant risk for in-hospital mortality. CONCLUSION: Short-term, in-hospital mortality is high among patients on chronic hemodialysis admitted for COVID-19 infection. They present similarly with the general population. Low PF ratio on admission and need for ventilation are independent risk factors for in-hospital mortality.
format Online
Article
Text
id pubmed-7898205
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Dove
record_format MEDLINE/PubMed
spelling pubmed-78982052021-02-23 Clinical Characteristics and Short-Term Outcomes of Chronic Dialysis Patients Admitted for COVID-19 in Metro Manila, Philippines Tomacruz, Isabelle Dominique So, Paolo Nikolai Pasilan, Renz Michael Camenforte, Jameel Kristine Duavit, Maria Isabel Int J Nephrol Renovasc Dis Original Research AIM: Data published on COVID-19 in the Filipino population, particularly those with end stage kidney disease (ESKD) are still lacking. METHODS: We performed a retrospective, observational study of 68 ESKD patients admitted with COVID-19 infection at a tertiary hospital in Metro Manila, Philippines from April 1, 2020 to July 31, 2020. We compared the clinical features, baseline laboratory data, treatment strategies and short-term outcomes between those who survived and those who died. We also determined the risk factors associated with mortality from COVID-19. RESULTS: Mean age was 54.5 years old, 66% were male. All patients admitted were on maintenance hemodialysis (HD). The most common presenting symptoms were dyspnea (57%), fever (47%) and cough (38%). There was an equal number of patients on high flow nasal cannula (17.7%) and invasive mechanical ventilation (17.7%). ICU admission was required in 17.7% of the cohort. In-hospital death occurred in 25% of the patients. Admission PaO(2)/FiO(2) (PF) ratios (162 ± 134 versus 356 ± 181; p=0.0009) were lower, and procalcitonin (6.07 ± 10.5ng/mL versus 0.73 ± 3.61 ng/mL; p=0.02), lactate dehydrogenase (396 ± 274U/L versus 282 ± 148 U/L; p=0.03), and white blood cell counts (10 ± 7.3 x 10(9)/L versus 6.3 ± 4.2 x 10(9)/L; p= 0.0039) were significantly higher among those who died compared to those who survived. After adjusting for confounders, only low PF ratio (HR 1.01 for every unit decrease, 95% CI 1–1.01) and need for ventilation (HR 6.45, 95% CI 1.16–35.97) conferred a significant risk for in-hospital mortality. CONCLUSION: Short-term, in-hospital mortality is high among patients on chronic hemodialysis admitted for COVID-19 infection. They present similarly with the general population. Low PF ratio on admission and need for ventilation are independent risk factors for in-hospital mortality. Dove 2021-02-17 /pmc/articles/PMC7898205/ /pubmed/33628044 http://dx.doi.org/10.2147/IJNRD.S287455 Text en © 2021 Tomacruz et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Tomacruz, Isabelle Dominique
So, Paolo Nikolai
Pasilan, Renz Michael
Camenforte, Jameel Kristine
Duavit, Maria Isabel
Clinical Characteristics and Short-Term Outcomes of Chronic Dialysis Patients Admitted for COVID-19 in Metro Manila, Philippines
title Clinical Characteristics and Short-Term Outcomes of Chronic Dialysis Patients Admitted for COVID-19 in Metro Manila, Philippines
title_full Clinical Characteristics and Short-Term Outcomes of Chronic Dialysis Patients Admitted for COVID-19 in Metro Manila, Philippines
title_fullStr Clinical Characteristics and Short-Term Outcomes of Chronic Dialysis Patients Admitted for COVID-19 in Metro Manila, Philippines
title_full_unstemmed Clinical Characteristics and Short-Term Outcomes of Chronic Dialysis Patients Admitted for COVID-19 in Metro Manila, Philippines
title_short Clinical Characteristics and Short-Term Outcomes of Chronic Dialysis Patients Admitted for COVID-19 in Metro Manila, Philippines
title_sort clinical characteristics and short-term outcomes of chronic dialysis patients admitted for covid-19 in metro manila, philippines
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898205/
https://www.ncbi.nlm.nih.gov/pubmed/33628044
http://dx.doi.org/10.2147/IJNRD.S287455
work_keys_str_mv AT tomacruzisabelledominique clinicalcharacteristicsandshorttermoutcomesofchronicdialysispatientsadmittedforcovid19inmetromanilaphilippines
AT sopaolonikolai clinicalcharacteristicsandshorttermoutcomesofchronicdialysispatientsadmittedforcovid19inmetromanilaphilippines
AT pasilanrenzmichael clinicalcharacteristicsandshorttermoutcomesofchronicdialysispatientsadmittedforcovid19inmetromanilaphilippines
AT camenfortejameelkristine clinicalcharacteristicsandshorttermoutcomesofchronicdialysispatientsadmittedforcovid19inmetromanilaphilippines
AT duavitmariaisabel clinicalcharacteristicsandshorttermoutcomesofchronicdialysispatientsadmittedforcovid19inmetromanilaphilippines