Cargando…

Aging-Associated Alterations in Mammary Epithelia and Stroma Revealed by Single-Cell RNA Sequencing

Aging is closely associated with increased susceptibility to breast cancer, yet there have been limited systematic studies of aging-induced alterations in the mammary gland. Here, we leverage high-throughput single-cell RNA sequencing to generate a detailed transcriptomic atlas of young and aged mur...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Carman Man-Chung, Shapiro, Hana, Tsiobikas, Christina, Selfors, Laura M., Chen, Huidong, Rosenbluth, Jennifer, Moore, Kaitlin, Gupta, Kushali P., Kenneth Gray, G., Oren, Yaara, Steinbaugh, Michael J., Guerriero, Jennifer L., Pinello, Luca, Regev, Aviv, Brugge, Joan S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898263/ https://www.ncbi.nlm.nih.gov/pubmed/33378681 http://dx.doi.org/10.1016/j.celrep.2020.108566

Ejemplares similares

Evidence for a multipotent mammary progenitor with pregnancy-specific activity
por: Kaanta, Alice S, et al.
Publicado: (2013)

CRB3 and the FERM protein EPB41L4B regulate proliferation of mammary epithelial cells through the release of amphiregulin
por: Walker, Stephanie J., et al.
Publicado: (2018)

Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages
por: Rosenbluth, Jennifer M., et al.
Publicado: (2020)

Deep proteome profiling of human mammary epithelia at lineage and age resolution
por: Hinz, Stefan, et al.
Publicado: (2021)

Editorial: The Mammary Stroma in Normal Development and Function
por: Schedin, Pepper, et al.
Publicado: (2010)

Laminin mediates tissue-specific gene expression in mammary epithelia
Publicado: (1995)

Disrupting the Balance between Tumor Epithelia and Stroma is a Possible Therapeutic Approach for Pancreatic Cancer
por: Wang, Zheng, et al.
Publicado: (2014)

Tumour-stromal interactions: Role of the stroma in mammary development
por: Silberstein, Gary B
Publicado: (2001)

Laminin and biomimetic extracellular elasticity enhance functional differentiation in mammary epithelia
por: Alcaraz, Jordi, et al.
Publicado: (2008)

Cellular Microenvironment Influences the Ability of Mammary Epithelia to Undergo Cell Cycle
por: Jeanes, Alexa I., et al.
Publicado: (2011)

In utero estrogenic endocrine disruption alters the stroma to increase extracellular matrix density and mammary gland stiffness
por: Wormsbaecher, Clarissa, et al.
Publicado: (2020)

Interlobular and intralobular mammary stroma: Genotype may not reflect phenotype
por: Fleming, JM, et al.
Publicado: (2008)

Development of Foreign Mammary Epithelial Morphology in the Stroma of Immunodeficient Mice
por: Rauner, Gat, et al.
Publicado: (2013)

Exposure to Low Doses of Oxybenzone During Perinatal Development Alters Mammary Gland Stroma in Female Mice
por: Matouskova, Klara, et al.
Publicado: (2022)

Focal Serous Tubal Intra-Epithelial Carcinoma Lesions Are Associated With Global Changes in the Fallopian Tube Epithelia and Stroma
por: Wu, Jingni, et al.
Publicado: (2022)

Prolactin and Dexamethasone Regulate Second Messenger-Stimulated Cl(−) Secretion in Mammary Epithelia
por: Anantamongkol, Utchariya, et al.
Publicado: (2012)

High-Dimensional Phenotyping Identifies Age-Emergent Cells in Human Mammary Epithelia
por: Pelissier Vatter, Fanny A., et al.
Publicado: (2018)

Evidence for accelerated aging in mammary epithelia of women carrying germline BRCA1 or BRCA2 mutations
por: Shalabi, Sundus F., et al.
Publicado: (2021)

Rac1 links integrin-mediated adhesion to the control of lactational differentiation in mammary epithelia
por: Akhtar, Nasreen, et al.
Publicado: (2006)

Abnormal Mammary Development in 129:STAT1-Null Mice is Stroma-Dependent
por: Chen, Jane Q., et al.
Publicado: (2015)

Serotonin stimulated parathyroid hormone related protein induction in the mammary epithelia by transglutaminase-dependent serotonylation
por: Sheftel, Celeste M., et al.
Publicado: (2020)

Mitochondrial Toxicity of Azithromycin Results in Aerobic Glycolysis and DNA Damage of Human Mammary Epithelia and Fibroblasts
por: Jiang, Xianpeng, et al.
Publicado: (2019)

RANK links senescence to stemness in the mammary epithelia, delaying tumor onset but increasing tumor aggressiveness
por: Benítez, Sandra, et al.
Publicado: (2021)

Tumour-stromal interactions: Phenotypic and genetic alterations in mammary stroma - implications for tumour progression
por: Schor, Seth L, et al.
Publicado: (2001)

pRb Inactivation in Mammary Cells Reveals Common Mechanisms for Tumor Initiation and Progression in Divergent Epithelia
por: Simin, Karl, et al.
Publicado: (2004)

The mitotic tensegrity guardian tau protects mammary epithelia from katanin-like1-induced aneuploidy
por: Sudo, Haruka, et al.
Publicado: (2016)

Colon stroma mediates an inflammation-driven fibroblastic response controlling matrix remodeling and healing
por: Jasso, Guadalupe J., et al.
Publicado: (2022)

Transporting Epithelia
por: Biber, Thomas U. L.
Publicado: (1974)

Airway Epithelia
por: Johnson, Larry G., et al.
Publicado: (2003)

The Epithelia of the Kidney
Publicado: (1882)

C. elegans Apical Extracellular Matrices Shape Epithelia
por: Cohen, Jennifer D., et al.
Publicado: (2020)

Identification of cancer genes that are independent of dominant proliferation and lineage programs
por: Selfors, Laura M., et al.
Publicado: (2017)

Niche-localized tumor cells are protected from HER2-targeted therapy via upregulation of an anti-apoptotic program in vivo
por: Zoeller, Jason J., et al.
Publicado: (2017)

Erratum: Niche-localized tumor cells are protected from HER2-targeted therapy via upregulation of an anti-apoptotic program in vivo
por: Zoeller, Jason J., et al.
Publicado: (2017)

Tamoxifen induces pleiotrophic changes in mammary stroma resulting in extracellular matrix that suppresses transformed phenotypes
por: Hattar, Rhonda, et al.
Publicado: (2009)

Tissue-resident macrophages promote extracellular matrix homeostasis in the mammary gland stroma of nulliparous mice
por: Wang, Ying, et al.
Publicado: (2020)

Improved development of somatic cell cloned bovine embryos by a mammary gland epithelia cells in vitro model
por: He, Xiao-ying, et al.
Publicado: (2016)

Conversion of ES cells to columnar epithelia by hensin and to squamous epithelia by laminin
por: Takito, Jiro, et al.
Publicado: (2004)

A planar polarized MYO6-DOCK7-RAC1 axis promotes tissue fluidification in mammary epithelia
por: Menin, Luca, et al.
Publicado: (2023)

GiniClust: detecting rare cell types from single-cell gene expression data with Gini index
por: Jiang, Lan, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_rnsafi1gs3500m5ekm0fpj1suo