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Mycobacterium simiae pulmonary infection: a case series and literature review
Incidence of Mycobacterium simiae pulmonary infection is increasing and diagnosis and treatment are challenging. We surveyed the clinical features, risk factors, diagnosis, and management in 20 patients from northeastern Iran diagnosed by line probe assay and confirmed by sequencing the ITS (16S‐23S...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898274/ https://www.ncbi.nlm.nih.gov/pubmed/33628451 http://dx.doi.org/10.1002/rcr2.719 |
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author | Lotfi, Hadi Sankian, Mojtaba Meshkat, Zahra Khalifeh Soltani, Ahmad Aryan, Ehsan |
author_facet | Lotfi, Hadi Sankian, Mojtaba Meshkat, Zahra Khalifeh Soltani, Ahmad Aryan, Ehsan |
author_sort | Lotfi, Hadi |
collection | PubMed |
description | Incidence of Mycobacterium simiae pulmonary infection is increasing and diagnosis and treatment are challenging. We surveyed the clinical features, risk factors, diagnosis, and management in 20 patients from northeastern Iran diagnosed by line probe assay and confirmed by sequencing the ITS (16S‐23S) rRNA region and carried out a literature review using the keywords “pulmonary infection” and “Mycobacterium simiae.” The mean age of patients was 55.1 years, with 80% female and 90% diagnosed by sputum. Clinical symptoms included severe cough (90%), sputum production (70%), haemoptysis (50%), and chest pain (35%). Comorbidities included a history of tuberculosis (60%), smoking (40%), or chronic obstructive pulmonary disease (20%). Patients were treated with levofloxacin, clarithromycin, and co‐trimoxazole. Except for two patients, the clinical symptoms improved. Mycobacterium simiae pulmonary infection is increasing in people with underlying diseases. Although choosing the most appropriate treatment remains a challenge, combining successful treatments could be useful in treating these patients. |
format | Online Article Text |
id | pubmed-7898274 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley & Sons, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-78982742021-02-23 Mycobacterium simiae pulmonary infection: a case series and literature review Lotfi, Hadi Sankian, Mojtaba Meshkat, Zahra Khalifeh Soltani, Ahmad Aryan, Ehsan Respirol Case Rep Case Series Incidence of Mycobacterium simiae pulmonary infection is increasing and diagnosis and treatment are challenging. We surveyed the clinical features, risk factors, diagnosis, and management in 20 patients from northeastern Iran diagnosed by line probe assay and confirmed by sequencing the ITS (16S‐23S) rRNA region and carried out a literature review using the keywords “pulmonary infection” and “Mycobacterium simiae.” The mean age of patients was 55.1 years, with 80% female and 90% diagnosed by sputum. Clinical symptoms included severe cough (90%), sputum production (70%), haemoptysis (50%), and chest pain (35%). Comorbidities included a history of tuberculosis (60%), smoking (40%), or chronic obstructive pulmonary disease (20%). Patients were treated with levofloxacin, clarithromycin, and co‐trimoxazole. Except for two patients, the clinical symptoms improved. Mycobacterium simiae pulmonary infection is increasing in people with underlying diseases. Although choosing the most appropriate treatment remains a challenge, combining successful treatments could be useful in treating these patients. John Wiley & Sons, Ltd 2021-02-22 /pmc/articles/PMC7898274/ /pubmed/33628451 http://dx.doi.org/10.1002/rcr2.719 Text en © 2021 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Case Series Lotfi, Hadi Sankian, Mojtaba Meshkat, Zahra Khalifeh Soltani, Ahmad Aryan, Ehsan Mycobacterium simiae pulmonary infection: a case series and literature review |
title |
Mycobacterium simiae pulmonary infection: a case series and literature review |
title_full |
Mycobacterium simiae pulmonary infection: a case series and literature review |
title_fullStr |
Mycobacterium simiae pulmonary infection: a case series and literature review |
title_full_unstemmed |
Mycobacterium simiae pulmonary infection: a case series and literature review |
title_short |
Mycobacterium simiae pulmonary infection: a case series and literature review |
title_sort | mycobacterium simiae pulmonary infection: a case series and literature review |
topic | Case Series |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898274/ https://www.ncbi.nlm.nih.gov/pubmed/33628451 http://dx.doi.org/10.1002/rcr2.719 |
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