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SynBio‐SynChem Approaches to Diversifying the Pacidamycins through the Exploitation of an Observed Pictet‐Spengler Reaction

A nonenzymatic Pictet‐Spengler reaction has been postulated to give rise to a subset of naturally occurring uridyl peptide antibiotics (UPAs). Here, using a combination of strain engineering and synthetic chemistry, we demonstrate that Pictet‐Spengler chemistry may be employed to generate even great...

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Detalles Bibliográficos
Autores principales:	Cartmell, Christopher, Abou Fayad, Antoine, Lynch, Rosemary, Sharma, Sunil V., Hauck, Nils, Gust, Bertolt, Goss, Rebecca J. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Full Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898326/ https://www.ncbi.nlm.nih.gov/pubmed/33058439 http://dx.doi.org/10.1002/cbic.202000594

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