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Cellular therapies in organ transplantation
Cellular therapy is a promising tool for improving the outcome of organ transplantation. Various cell types with different immunoregulatory and regenerative properties may find application for specific transplant rejection or injury‐related indications. The current era is crucial for the development...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898347/ https://www.ncbi.nlm.nih.gov/pubmed/33207013 http://dx.doi.org/10.1111/tri.13789 |
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author | Hoogduijn, Martin J. Issa, Fadi Casiraghi, Federica Reinders, Marlies E. J. |
author_facet | Hoogduijn, Martin J. Issa, Fadi Casiraghi, Federica Reinders, Marlies E. J. |
author_sort | Hoogduijn, Martin J. |
collection | PubMed |
description | Cellular therapy is a promising tool for improving the outcome of organ transplantation. Various cell types with different immunoregulatory and regenerative properties may find application for specific transplant rejection or injury‐related indications. The current era is crucial for the development of cellular therapies. Preclinical models have demonstrated the feasibility of efficacious cell therapy in transplantation, early clinical trials have shown safety of several of these therapies, and the first steps towards efficacy studies in humans have been made. In this review, we address the current state of the art of cellular therapies in clinical transplantation and discuss monitoring tools and endpoints for these studies. |
format | Online Article Text |
id | pubmed-7898347 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78983472021-03-03 Cellular therapies in organ transplantation Hoogduijn, Martin J. Issa, Fadi Casiraghi, Federica Reinders, Marlies E. J. Transpl Int Reviews Cellular therapy is a promising tool for improving the outcome of organ transplantation. Various cell types with different immunoregulatory and regenerative properties may find application for specific transplant rejection or injury‐related indications. The current era is crucial for the development of cellular therapies. Preclinical models have demonstrated the feasibility of efficacious cell therapy in transplantation, early clinical trials have shown safety of several of these therapies, and the first steps towards efficacy studies in humans have been made. In this review, we address the current state of the art of cellular therapies in clinical transplantation and discuss monitoring tools and endpoints for these studies. John Wiley and Sons Inc. 2021-01-15 2021-02 /pmc/articles/PMC7898347/ /pubmed/33207013 http://dx.doi.org/10.1111/tri.13789 Text en © 2020 The Authors. Transplant International published by John Wiley & Sons Ltd on behalf of Steunstichting ESOT This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Reviews Hoogduijn, Martin J. Issa, Fadi Casiraghi, Federica Reinders, Marlies E. J. Cellular therapies in organ transplantation |
title | Cellular therapies in organ transplantation |
title_full | Cellular therapies in organ transplantation |
title_fullStr | Cellular therapies in organ transplantation |
title_full_unstemmed | Cellular therapies in organ transplantation |
title_short | Cellular therapies in organ transplantation |
title_sort | cellular therapies in organ transplantation |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898347/ https://www.ncbi.nlm.nih.gov/pubmed/33207013 http://dx.doi.org/10.1111/tri.13789 |
work_keys_str_mv | AT hoogduijnmartinj cellulartherapiesinorgantransplantation AT issafadi cellulartherapiesinorgantransplantation AT casiraghifederica cellulartherapiesinorgantransplantation AT reindersmarliesej cellulartherapiesinorgantransplantation |