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Cellular therapies in organ transplantation

Cellular therapy is a promising tool for improving the outcome of organ transplantation. Various cell types with different immunoregulatory and regenerative properties may find application for specific transplant rejection or injury‐related indications. The current era is crucial for the development...

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Detalles Bibliográficos
Autores principales: Hoogduijn, Martin J., Issa, Fadi, Casiraghi, Federica, Reinders, Marlies E. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898347/
https://www.ncbi.nlm.nih.gov/pubmed/33207013
http://dx.doi.org/10.1111/tri.13789
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author Hoogduijn, Martin J.
Issa, Fadi
Casiraghi, Federica
Reinders, Marlies E. J.
author_facet Hoogduijn, Martin J.
Issa, Fadi
Casiraghi, Federica
Reinders, Marlies E. J.
author_sort Hoogduijn, Martin J.
collection PubMed
description Cellular therapy is a promising tool for improving the outcome of organ transplantation. Various cell types with different immunoregulatory and regenerative properties may find application for specific transplant rejection or injury‐related indications. The current era is crucial for the development of cellular therapies. Preclinical models have demonstrated the feasibility of efficacious cell therapy in transplantation, early clinical trials have shown safety of several of these therapies, and the first steps towards efficacy studies in humans have been made. In this review, we address the current state of the art of cellular therapies in clinical transplantation and discuss monitoring tools and endpoints for these studies.
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spelling pubmed-78983472021-03-03 Cellular therapies in organ transplantation Hoogduijn, Martin J. Issa, Fadi Casiraghi, Federica Reinders, Marlies E. J. Transpl Int Reviews Cellular therapy is a promising tool for improving the outcome of organ transplantation. Various cell types with different immunoregulatory and regenerative properties may find application for specific transplant rejection or injury‐related indications. The current era is crucial for the development of cellular therapies. Preclinical models have demonstrated the feasibility of efficacious cell therapy in transplantation, early clinical trials have shown safety of several of these therapies, and the first steps towards efficacy studies in humans have been made. In this review, we address the current state of the art of cellular therapies in clinical transplantation and discuss monitoring tools and endpoints for these studies. John Wiley and Sons Inc. 2021-01-15 2021-02 /pmc/articles/PMC7898347/ /pubmed/33207013 http://dx.doi.org/10.1111/tri.13789 Text en © 2020 The Authors. Transplant International published by John Wiley & Sons Ltd on behalf of Steunstichting ESOT This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Reviews
Hoogduijn, Martin J.
Issa, Fadi
Casiraghi, Federica
Reinders, Marlies E. J.
Cellular therapies in organ transplantation
title Cellular therapies in organ transplantation
title_full Cellular therapies in organ transplantation
title_fullStr Cellular therapies in organ transplantation
title_full_unstemmed Cellular therapies in organ transplantation
title_short Cellular therapies in organ transplantation
title_sort cellular therapies in organ transplantation
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898347/
https://www.ncbi.nlm.nih.gov/pubmed/33207013
http://dx.doi.org/10.1111/tri.13789
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