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Distinct contributions of cathelin‐related antimicrobial peptide (CRAMP) derived from epithelial cells and macrophages to colon mucosal homeostasis

The cathelin‐related antimicrobial peptide CRAMP protects the mouse colon from inflammation, inflammation‐associated carcinogenesis, and disrupted microbiome balance, as shown in systemic Cnlp (−/−) mice (also known as Camp (−/−) mice). However, the mechanistic basis for the role and the cellular so...

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Autores principales: Chen, Keqiang, Yoshimura, Teizo, Yao, Xiaohong, Gong, Wanghua, Huang, Jiaqiang, Dzutsev, Amiran K, McCulloch, John, O'hUigin, Colm, Bian, Xiu‐wu, Trinchieri, Giorgio, Wang, Ji Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898386/
https://www.ncbi.nlm.nih.gov/pubmed/33104252
http://dx.doi.org/10.1002/path.5572
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author Chen, Keqiang
Yoshimura, Teizo
Yao, Xiaohong
Gong, Wanghua
Huang, Jiaqiang
Dzutsev, Amiran K
McCulloch, John
O'hUigin, Colm
Bian, Xiu‐wu
Trinchieri, Giorgio
Wang, Ji Ming
author_facet Chen, Keqiang
Yoshimura, Teizo
Yao, Xiaohong
Gong, Wanghua
Huang, Jiaqiang
Dzutsev, Amiran K
McCulloch, John
O'hUigin, Colm
Bian, Xiu‐wu
Trinchieri, Giorgio
Wang, Ji Ming
author_sort Chen, Keqiang
collection PubMed
description The cathelin‐related antimicrobial peptide CRAMP protects the mouse colon from inflammation, inflammation‐associated carcinogenesis, and disrupted microbiome balance, as shown in systemic Cnlp (−/−) mice (also known as Camp (−/−) mice). However, the mechanistic basis for the role and the cellular source of CRAMP in colon pathophysiology are ill defined. This study, using either epithelial or myeloid conditional Cnlp (−/−) mice, demonstrated that epithelial cell‐derived CRAMP played a major role in supporting normal development of colon crypts, mucus production, and repair of injured mucosa. On the other hand, myeloid cell‐derived CRAMP potently supported colon epithelial resistance to bacterial invasion during acute inflammation with exacerbated mucosal damage and higher rate of mouse mortality. Therefore, a well concerted cooperation of epithelial‐ and myeloid‐derived CRAMP is essential for colon mucosal homeostasis. © 2020 The Authors. The Journal of Pathology published by John Wiley & Sons, Ltd. on behalf of The Pathological Society of Great Britain and Ireland.
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spelling pubmed-78983862021-03-03 Distinct contributions of cathelin‐related antimicrobial peptide (CRAMP) derived from epithelial cells and macrophages to colon mucosal homeostasis Chen, Keqiang Yoshimura, Teizo Yao, Xiaohong Gong, Wanghua Huang, Jiaqiang Dzutsev, Amiran K McCulloch, John O'hUigin, Colm Bian, Xiu‐wu Trinchieri, Giorgio Wang, Ji Ming J Pathol Original Papers The cathelin‐related antimicrobial peptide CRAMP protects the mouse colon from inflammation, inflammation‐associated carcinogenesis, and disrupted microbiome balance, as shown in systemic Cnlp (−/−) mice (also known as Camp (−/−) mice). However, the mechanistic basis for the role and the cellular source of CRAMP in colon pathophysiology are ill defined. This study, using either epithelial or myeloid conditional Cnlp (−/−) mice, demonstrated that epithelial cell‐derived CRAMP played a major role in supporting normal development of colon crypts, mucus production, and repair of injured mucosa. On the other hand, myeloid cell‐derived CRAMP potently supported colon epithelial resistance to bacterial invasion during acute inflammation with exacerbated mucosal damage and higher rate of mouse mortality. Therefore, a well concerted cooperation of epithelial‐ and myeloid‐derived CRAMP is essential for colon mucosal homeostasis. © 2020 The Authors. The Journal of Pathology published by John Wiley & Sons, Ltd. on behalf of The Pathological Society of Great Britain and Ireland. John Wiley & Sons, Ltd 2021-01-19 2021-03 /pmc/articles/PMC7898386/ /pubmed/33104252 http://dx.doi.org/10.1002/path.5572 Text en © 2020 The Authors. The Journal of Pathology published by John Wiley & Sons, Ltd. on behalf of The Pathological Society of Great Britain and Ireland. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Papers
Chen, Keqiang
Yoshimura, Teizo
Yao, Xiaohong
Gong, Wanghua
Huang, Jiaqiang
Dzutsev, Amiran K
McCulloch, John
O'hUigin, Colm
Bian, Xiu‐wu
Trinchieri, Giorgio
Wang, Ji Ming
Distinct contributions of cathelin‐related antimicrobial peptide (CRAMP) derived from epithelial cells and macrophages to colon mucosal homeostasis
title Distinct contributions of cathelin‐related antimicrobial peptide (CRAMP) derived from epithelial cells and macrophages to colon mucosal homeostasis
title_full Distinct contributions of cathelin‐related antimicrobial peptide (CRAMP) derived from epithelial cells and macrophages to colon mucosal homeostasis
title_fullStr Distinct contributions of cathelin‐related antimicrobial peptide (CRAMP) derived from epithelial cells and macrophages to colon mucosal homeostasis
title_full_unstemmed Distinct contributions of cathelin‐related antimicrobial peptide (CRAMP) derived from epithelial cells and macrophages to colon mucosal homeostasis
title_short Distinct contributions of cathelin‐related antimicrobial peptide (CRAMP) derived from epithelial cells and macrophages to colon mucosal homeostasis
title_sort distinct contributions of cathelin‐related antimicrobial peptide (cramp) derived from epithelial cells and macrophages to colon mucosal homeostasis
topic Original Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898386/
https://www.ncbi.nlm.nih.gov/pubmed/33104252
http://dx.doi.org/10.1002/path.5572
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