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Distinct contributions of cathelin‐related antimicrobial peptide (CRAMP) derived from epithelial cells and macrophages to colon mucosal homeostasis
The cathelin‐related antimicrobial peptide CRAMP protects the mouse colon from inflammation, inflammation‐associated carcinogenesis, and disrupted microbiome balance, as shown in systemic Cnlp (−/−) mice (also known as Camp (−/−) mice). However, the mechanistic basis for the role and the cellular so...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898386/ https://www.ncbi.nlm.nih.gov/pubmed/33104252 http://dx.doi.org/10.1002/path.5572 |
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author | Chen, Keqiang Yoshimura, Teizo Yao, Xiaohong Gong, Wanghua Huang, Jiaqiang Dzutsev, Amiran K McCulloch, John O'hUigin, Colm Bian, Xiu‐wu Trinchieri, Giorgio Wang, Ji Ming |
author_facet | Chen, Keqiang Yoshimura, Teizo Yao, Xiaohong Gong, Wanghua Huang, Jiaqiang Dzutsev, Amiran K McCulloch, John O'hUigin, Colm Bian, Xiu‐wu Trinchieri, Giorgio Wang, Ji Ming |
author_sort | Chen, Keqiang |
collection | PubMed |
description | The cathelin‐related antimicrobial peptide CRAMP protects the mouse colon from inflammation, inflammation‐associated carcinogenesis, and disrupted microbiome balance, as shown in systemic Cnlp (−/−) mice (also known as Camp (−/−) mice). However, the mechanistic basis for the role and the cellular source of CRAMP in colon pathophysiology are ill defined. This study, using either epithelial or myeloid conditional Cnlp (−/−) mice, demonstrated that epithelial cell‐derived CRAMP played a major role in supporting normal development of colon crypts, mucus production, and repair of injured mucosa. On the other hand, myeloid cell‐derived CRAMP potently supported colon epithelial resistance to bacterial invasion during acute inflammation with exacerbated mucosal damage and higher rate of mouse mortality. Therefore, a well concerted cooperation of epithelial‐ and myeloid‐derived CRAMP is essential for colon mucosal homeostasis. © 2020 The Authors. The Journal of Pathology published by John Wiley & Sons, Ltd. on behalf of The Pathological Society of Great Britain and Ireland. |
format | Online Article Text |
id | pubmed-7898386 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley & Sons, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-78983862021-03-03 Distinct contributions of cathelin‐related antimicrobial peptide (CRAMP) derived from epithelial cells and macrophages to colon mucosal homeostasis Chen, Keqiang Yoshimura, Teizo Yao, Xiaohong Gong, Wanghua Huang, Jiaqiang Dzutsev, Amiran K McCulloch, John O'hUigin, Colm Bian, Xiu‐wu Trinchieri, Giorgio Wang, Ji Ming J Pathol Original Papers The cathelin‐related antimicrobial peptide CRAMP protects the mouse colon from inflammation, inflammation‐associated carcinogenesis, and disrupted microbiome balance, as shown in systemic Cnlp (−/−) mice (also known as Camp (−/−) mice). However, the mechanistic basis for the role and the cellular source of CRAMP in colon pathophysiology are ill defined. This study, using either epithelial or myeloid conditional Cnlp (−/−) mice, demonstrated that epithelial cell‐derived CRAMP played a major role in supporting normal development of colon crypts, mucus production, and repair of injured mucosa. On the other hand, myeloid cell‐derived CRAMP potently supported colon epithelial resistance to bacterial invasion during acute inflammation with exacerbated mucosal damage and higher rate of mouse mortality. Therefore, a well concerted cooperation of epithelial‐ and myeloid‐derived CRAMP is essential for colon mucosal homeostasis. © 2020 The Authors. The Journal of Pathology published by John Wiley & Sons, Ltd. on behalf of The Pathological Society of Great Britain and Ireland. John Wiley & Sons, Ltd 2021-01-19 2021-03 /pmc/articles/PMC7898386/ /pubmed/33104252 http://dx.doi.org/10.1002/path.5572 Text en © 2020 The Authors. The Journal of Pathology published by John Wiley & Sons, Ltd. on behalf of The Pathological Society of Great Britain and Ireland. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Papers Chen, Keqiang Yoshimura, Teizo Yao, Xiaohong Gong, Wanghua Huang, Jiaqiang Dzutsev, Amiran K McCulloch, John O'hUigin, Colm Bian, Xiu‐wu Trinchieri, Giorgio Wang, Ji Ming Distinct contributions of cathelin‐related antimicrobial peptide (CRAMP) derived from epithelial cells and macrophages to colon mucosal homeostasis |
title | Distinct contributions of cathelin‐related antimicrobial peptide (CRAMP) derived from epithelial cells and macrophages to colon mucosal homeostasis |
title_full | Distinct contributions of cathelin‐related antimicrobial peptide (CRAMP) derived from epithelial cells and macrophages to colon mucosal homeostasis |
title_fullStr | Distinct contributions of cathelin‐related antimicrobial peptide (CRAMP) derived from epithelial cells and macrophages to colon mucosal homeostasis |
title_full_unstemmed | Distinct contributions of cathelin‐related antimicrobial peptide (CRAMP) derived from epithelial cells and macrophages to colon mucosal homeostasis |
title_short | Distinct contributions of cathelin‐related antimicrobial peptide (CRAMP) derived from epithelial cells and macrophages to colon mucosal homeostasis |
title_sort | distinct contributions of cathelin‐related antimicrobial peptide (cramp) derived from epithelial cells and macrophages to colon mucosal homeostasis |
topic | Original Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898386/ https://www.ncbi.nlm.nih.gov/pubmed/33104252 http://dx.doi.org/10.1002/path.5572 |
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