Chemical and Genetic Studies on the Formation of Pyrrolones During the Biosynthesis of Cytochalasans

A key step during the biosynthesis of cytochalasans is a proposed Knoevenagel condensation to form the pyrrolone core, enabling the subsequent 4+2 cycloaddition reaction that results in the characteristic octahydroisoindolone motif of all cytochalasans. In this work, we investigate the role of the h...

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Detalles Bibliográficos
Autores principales: Zhang, Haili, Hantke, Verena, Bruhnke, Pia, Skellam, Elizabeth J., Cox, Russell J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898483/
https://www.ncbi.nlm.nih.gov/pubmed/33146923
http://dx.doi.org/10.1002/chem.202004444

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898483/
https://www.ncbi.nlm.nih.gov/pubmed/33146923
http://dx.doi.org/10.1002/chem.202004444

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