Cargando…

Multimerin 1 supports platelet function in vivo and binds to specific GPAGPOGPX motifs in fibrillar collagens that enhance platelet adhesion

BACKGROUND: Multimerin 1 (human: MMRN1, mouse: Mmrn1) is a homopolymeric, adhesive, platelet and endothelial protein that binds to von Willebrand factor and enhances platelet adhesion to fibrillar collagen ex vivo. OBJECTIVES: To examine the impact of Mmrn1 deficiency on platelet adhesive function,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Leatherdale, Alexander, Parker, D’Andra, Tasneem, Subia, Wang, Yiming, Bihan, Dominique, Bonna, Arkadiusz, Hamaia, Samir W., Gross, Peter L., Ni, Heyu, Doble, Bradley W., Lillicrap, David, Farndale, Richard W., Hayward, Catherine P. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	PLATELETS
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898486/ https://www.ncbi.nlm.nih.gov/pubmed/33179420 http://dx.doi.org/10.1111/jth.15171

Ejemplares similares

The Functions of the A1A2A3 Domains in Von Willebrand Factor Include Multimerin 1 Binding
por: Parker, D’Andra N., et al.
Publicado: (2016)

Platelet collagen receptor Glycoprotein VI‐dimer recognizes fibrinogen and fibrin through their D‐domains, contributing to platelet adhesion and activation during thrombus formation
por: Induruwa, I., et al.
Publicado: (2018)

Modified platelet deposition on matrix metalloproteinase 13 digested collagen I
por: Howes, J.‐M., et al.
Publicado: (2015)

Cleavage by MMP‐13 renders VWF unable to bind to collagen but increases its platelet reactivity
por: Howes, Joanna‐Marie, et al.
Publicado: (2020)

Clustering of glycoprotein VI (GPVI) dimers upon adhesion to collagen as a mechanism to regulate GPVI signaling in platelets
por: Poulter, N. S., et al.
Publicado: (2017)

The chaperone protein HSP47: a platelet collagen binding protein that contributes to thrombosis and hemostasis
por: Sasikumar, P., et al.
Publicado: (2018)

SMIFH2 inhibition of platelets demonstrates a critical role for formin proteins in platelet cytoskeletal dynamics
por: Green, Hannah L. H., et al.
Publicado: (2020)

The platelet-surface thiol isomerase enzyme ERp57 modulates platelet function
por: Holbrook, L-M, et al.
Publicado: (2012)

Mean platelet size related to glycoprotein-specific autoantibodies and platelet-associated IgG
por: JAVELA, K, et al.
Publicado: (2007)

Activation mechanism dependent surface exposure of cellular factor XIII on activated platelets and platelet microparticles
por: Somodi, Laura, et al.
Publicado: (2022)

Manipulating megakaryocytes to manufacture platelets ex vivo
por: Karagiannis, P, et al.
Publicado: (2015)

Super‐resolution microscopy as a potential approach to diagnosis of platelet granule disorders
por: Westmoreland, D., et al.
Publicado: (2016)

Non-genomic effects of PPARγ ligands: inhibition of GPVI-stimulated platelet activation
por: Moraes, L A, et al.
Publicado: (2010)

Measurement of procoagulant platelets provides mechanistic insight and diagnostic potential in heparin‐induced thrombocytopenia
por: Lee, Christine S. M., et al.
Publicado: (2022)

Amplification of human platelet activation by surface pannexin-1 channels
por: Taylor, K A, et al.
Publicado: (2014)

Circulating primers enhance platelet function and induce resistance to antiplatelet therapy
por: Blair, T A, et al.
Publicado: (2015)

Anti‐platelet antibodies in childhood immune thrombocytopenia: Prevalence and prognostic implications
por: Schmidt, David E., et al.
Publicado: (2020)

Cytohesin-2 phosphorylation by protein kinase C relieves the constitutive suppression of platelet dense granule secretion by ADP-ribosylation factor 6
por: van den Bosch, M T J, et al.
Publicado: (2014)

Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2
por: HUGHES, C E, et al.
Publicado: (2008)

The formyl peptide fMLF primes platelet activation and augments thrombus formation
por: Salamah, Maryam F., et al.
Publicado: (2019)

Phagocytosis by endothelial cells inhibits procoagulant activity of platelets of essential thrombocythemia in vitro
por: Ji, Shuting, et al.
Publicado: (2019)

Removal of platelets from blood plasma to improve the quality of extracellular vesicle research
por: Bettin, Britta, et al.
Publicado: (2022)

Localized endothelial‐based control of platelet aggregation and coagulation under flow: A proof‐of‐principle vessel‐on‐a‐chip study
por: Brouns, Sanne L.N., et al.
Publicado: (2020)

Dimeric FcγR ectodomains detect pathogenic anti‐platelet factor 4–heparin antibodies in heparin‐induced thromobocytopenia
por: Wines, B. D., et al.
Publicado: (2018)

Platelet endothelial cell adhesion molecule-1 regulates collagen-stimulated platelet function by modulating the association of phosphatidylinositol 3-kinase with Grb-2-associated binding protein-1 and linker for activation of T cells
por: Moraes, L A, et al.
Publicado: (2010)

Protein kinase C and P2Y(12) take center stage in thrombin-mediated activation of mammalian target of rapamycin complex 1 in human platelets
por: Moore, S F, et al.
Publicado: (2014)

Diagnostic utility of the ISTH bleeding assessment tool in patients with suspected platelet function disorders
por: Adler, Marcel, et al.
Publicado: (2019)

Flow cytometric mepacrine fluorescence can be used for the exclusion of platelet dense granule deficiency
por: van Asten, Ivar, et al.
Publicado: (2019)

Platelet count and indices as postpartum hemorrhage risk factors: a retrospective cohort study
por: van Dijk, Wobke E. M., et al.
Publicado: (2021)

Maintaining flippase activity in procoagulant platelets is a novel approach to reducing thrombin generation
por: Millington‐Burgess, Sarah L., et al.
Publicado: (2022)

A gain‐of‐function filamin A mutation in mouse platelets induces thrombus instability
por: Adam, Frédéric, et al.
Publicado: (2022)

CLEC‐2‐dependent activation of mouse platelets is weakly inhibited by cAMP but not by cGMP
por: Borgognone, A., et al.
Publicado: (2014)

Novel assay demonstrates that coronary artery disease patients have heightened procoagulant platelet response
por: Pasalic, L., et al.
Publicado: (2018)

Altered Fc glycosylation of anti‐HLA alloantibodies in hemato‐oncological patients receiving platelet transfusions
por: van Osch, Thijs L. J., et al.
Publicado: (2022)

Ca(v)3.2 T‐type calcium channel regulates mouse platelet activation and arterial thrombosis
por: Tamang, Hem Kumar, et al.
Publicado: (2022)

Hypothermia‐induced activation of the splenic platelet pool as a risk factor for thrombotic disease in a mouse model
por: Horioka, Kie, et al.
Publicado: (2019)

The fate of mitochondria during platelet activation
por: Grichine, Alexei, et al.
Publicado: (2023)

Use of next‐generation sequencing and candidate gene analysis to identify underlying defects in patients with inherited platelet function disorders
por: Leo, V. C., et al.
Publicado: (2015)

A humanized monoclonal antibody that inhibits platelet‐surface ERp72 reveals a role for ERp72 in thrombosis
por: Holbrook, L.‐M., et al.
Publicado: (2018)

Effect of heparanase inhibitor on tissue factor overexpression in platelets and endothelial cells induced by anti‐β2‐GPI antibodies
por: Capozzi, Antonella, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_98gevpc6usd58ec7dfff7e1lra