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Dynamics of epidemic diseases without guaranteed immunity
The pandemic of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) suggests a novel type of disease spread dynamics. We here study the case where infected agents recover and only develop immunity if they are continuously infected for some time τ. For large τ, the disease model is described...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898496/ https://www.ncbi.nlm.nih.gov/pubmed/33643763 http://dx.doi.org/10.1186/s13362-021-00101-y |
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author | Langfeld, Kurt |
author_facet | Langfeld, Kurt |
author_sort | Langfeld, Kurt |
collection | PubMed |
description | The pandemic of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) suggests a novel type of disease spread dynamics. We here study the case where infected agents recover and only develop immunity if they are continuously infected for some time τ. For large τ, the disease model is described by a statistical field theory. Hence, the phases of the underlying field theory characterise the disease dynamics: (i) a pandemic phase and (ii) a response regime. The statistical field theory provides an upper bound of the peak rate of infected agents. An effective control strategy needs to aim to keep the disease in the response regime (no ‘second’ wave). The model is tested at the quantitative level using an idealised disease network. The model excellently describes the epidemic spread of the SARS-CoV-2 outbreak in the city of Wuhan, China. We find that only 30% of the recovered agents have developed immunity. |
format | Online Article Text |
id | pubmed-7898496 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-78984962021-02-23 Dynamics of epidemic diseases without guaranteed immunity Langfeld, Kurt J Math Ind Research The pandemic of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) suggests a novel type of disease spread dynamics. We here study the case where infected agents recover and only develop immunity if they are continuously infected for some time τ. For large τ, the disease model is described by a statistical field theory. Hence, the phases of the underlying field theory characterise the disease dynamics: (i) a pandemic phase and (ii) a response regime. The statistical field theory provides an upper bound of the peak rate of infected agents. An effective control strategy needs to aim to keep the disease in the response regime (no ‘second’ wave). The model is tested at the quantitative level using an idealised disease network. The model excellently describes the epidemic spread of the SARS-CoV-2 outbreak in the city of Wuhan, China. We find that only 30% of the recovered agents have developed immunity. Springer Berlin Heidelberg 2021-02-22 2021 /pmc/articles/PMC7898496/ /pubmed/33643763 http://dx.doi.org/10.1186/s13362-021-00101-y Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Langfeld, Kurt Dynamics of epidemic diseases without guaranteed immunity |
title | Dynamics of epidemic diseases without guaranteed immunity |
title_full | Dynamics of epidemic diseases without guaranteed immunity |
title_fullStr | Dynamics of epidemic diseases without guaranteed immunity |
title_full_unstemmed | Dynamics of epidemic diseases without guaranteed immunity |
title_short | Dynamics of epidemic diseases without guaranteed immunity |
title_sort | dynamics of epidemic diseases without guaranteed immunity |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898496/ https://www.ncbi.nlm.nih.gov/pubmed/33643763 http://dx.doi.org/10.1186/s13362-021-00101-y |
work_keys_str_mv | AT langfeldkurt dynamicsofepidemicdiseaseswithoutguaranteedimmunity |