Cargando…

Panax quinquefolius L. Saponins Protect Myocardial Ischemia Reperfusion No-Reflow Through Inhibiting the Activation of NLRP3 Inflammasome via TLR4/MyD88/NF-κB Signaling Pathway

At present, many patients who undergo reperfusion immediately after percutaneous coronary intervention will undergo microvascular obstruction and reduction in myocardial blood flow. This phenomenon is called “no-reflow (NR),” and there is still no effective therapy for NR. Studies showed Panax quinq...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yu, Ping, Li, Yuangeng, Fu, Wenwen, Li, Xin, Liu, Yanzhe, Wang, Yaozhen, Yu, Xiaofeng, Xu, Huali, Sui, Dayun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898550/ https://www.ncbi.nlm.nih.gov/pubmed/33628178 http://dx.doi.org/10.3389/fphar.2020.607813

Ejemplares similares

Metabolomes and transcriptomes revealed the saponin distribution in root tissues of Panax quinquefolius and Panax notoginseng
por: Wei, Guangfei, et al.
Publicado: (2020)

MyD88 in Macrophages Enhances Liver Fibrosis by Activation of NLRP3 Inflammasome in HSCs
por: Ge, Shuang, et al.
Publicado: (2021)

Anti-tumor activities of Panax quinquefolius saponins and potential biomarkers in prostate cancer
por: He, Shan, et al.
Publicado: (2021)

A review for discovering bioactive minor saponins and biotransformative metabolites in Panax quinquefolius L.
por: Yang, Zhiyou, et al.
Publicado: (2022)

MyD88 in macrophages protects against colitis via inhibiting the activation of NLRP3 inflammasome in epithelial cells
por: Liu, Shi, et al.
Publicado: (2022)

Panax ginseng and Panax quinquefolius: From pharmacology to toxicology
por: Mancuso, Cesare, et al.
Publicado: (2017)

Atorvastatin suppresses NLRP3 inflammasome activation in intracerebral hemorrhage via TLR4- and MyD88-dependent pathways
por: Chen, Duo, et al.
Publicado: (2022)

Interaction of Panax quinquefolius Saponin and Dual Antiplatelets on Vascular Endothelial Function in Rats with Acute Myocardial Infarction
por: Wang, Baojun, et al.
Publicado: (2015)

Nephroprotective Effects of Saponins from Leaves of Panax quinquefolius against Cisplatin-Induced Acute Kidney Injury
por: Ma, Zhi-Na, et al.
Publicado: (2017)

Baicalein ameliorates TNBS-induced colitis by suppressing TLR4/MyD88 signaling cascade and NLRP3 inflammasome activation in mice
por: Luo, Xiaoping, et al.
Publicado: (2017)

The Effects of Panax ginseng and Panax quinquefolius on Thermoregulation in Animal Models
por: Hong, Bin Na, et al.
Publicado: (2015)

MyD88 and beyond: a perspective on MyD88-targeted therapeutic approach for modulation of host immunity
por: Saikh, Kamal U.
Publicado: (2021)

Schisandrin B Attenuates Diabetic Cardiomyopathy by Targeting MyD88 and Inhibiting MyD88‐Dependent Inflammation
por: Luo, Wu, et al.
Publicado: (2022)

A MyD88 meddles with survival
por: Bashyam, Hema
Publicado: (2007)

Role of MyD88 in Adenovirus Keratitis
por: Zhou, Xiaohong, et al.
Publicado: (2016)

Ginsenoside Rc Ameliorates Endothelial Insulin Resistance via Upregulation of Angiotensin-Converting Enzyme 2
por: Wang, Yaozhen, et al.
Publicado: (2021)

Proteopathic tau primes and activates interleukin-1β via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway
por: Jiang, Shanya, et al.
Publicado: (2021)

Cytohistological study of the leaf structures of Panax ginseng Meyer and Panax quinquefolius L.
por: Lee, Ok Ran, et al.
Publicado: (2017)

Soyasaponins reduce inflammation by downregulating MyD88 expression and suppressing the recruitments of TLR4 and MyD88 into lipid rafts
por: Chen, Junbin, et al.
Publicado: (2020)

MyD88 deficiency aggravates the severity of acute pancreatitis by promoting MyD88-independent TRIF pathway-mediated necrosis
por: Yang, Du-Jiang, et al.
Publicado: (2022)

MyD88 Polymorphisms and Association with Susceptibility to Salmonella Pullorum
por: Liu, Xian-Qing, et al.
Publicado: (2015)

MyD88 contribution to ocular surface homeostasis
por: Reins, Rose Y., et al.
Publicado: (2017)

Mechanism of MyD88S mediated signal termination
por: Pustelny, Katarzyna, et al.
Publicado: (2022)

A Novel Kindred with MyD88 Deficiency
por: Bucciol, Giorgia, et al.
Publicado: (2022)

Chemical and bioactive comparison of flowers of Panax ginseng Meyer, Panax quinquefolius L., and Panax notoginseng Burk.
por: Li, Fang, et al.
Publicado: (2017)

Mucus clearance, MyD88-dependent and MyD88-independent immunity modulate lung susceptibility to spontaneous bacterial infection and inflammation
por: Livraghi-Butrico, Alessandra, et al.
Publicado: (2012)

Chemical constituents from acid hydrolyzates of Panax quinquefolius total saponins and their inhibition activity to α-glycosidase and protein tyrosine phosphatase 1B
por: Han, Si-wen, et al.
Publicado: (2020)

Protective effect of Panax quinquefolium 20(S)-protopanaxadiol saponins, isolated from Pana quinquefolium, on permanent focal cerebral ischemic injury in rats
por: XU, HUALI, et al.
Publicado: (2014)

Hepatocyte-specific regulation of autophagy and inflammasome activation via MyD88 during lethal Ehrlichia infection
por: Teymournejad, Omid, et al.
Publicado: (2023)

Comparative Pharmacokinetic Studies of Four Ginsenosides in Rat Plasma by UPLC-MS/MS after Oral Administration of Panax quinquefolius-Acorus gramineus and Panax quinquefolius Extracts
por: Xie, Hailong, et al.
Publicado: (2019)

Panax quinquefolius saponins combined with dual antiplatelet therapy enhanced platelet inhibition with alleviated gastric injury via regulating eicosanoids metabolism
por: Wang, Wenting, et al.
Publicado: (2023)

Matrine inhibits IL-1β secretion in primary porcine alveolar macrophages through the MyD88/NF-κB pathway and NLRP3 inflammasome
por: Sun, Panpan, et al.
Publicado: (2019)

Mycoplasma gallisepticum triggers immune damage in the chicken thymus by activating the TLR-2/MyD88/NF-κB signaling pathway and NLRP3 inflammasome
por: Chen, Chunli, et al.
Publicado: (2020)

Panax notoginseng saponins inhibits NLRP3 inflammasome-mediated pyroptosis by downregulating lncRNA-ANRIL in cardiorenal syndrome type 4
por: Xu, Ying, et al.
Publicado: (2023)

Identification and Function of Myeloid Differentiation Factor 88 (MyD88) in Litopenaeus vannamei
por: Zhang, Shuang, et al.
Publicado: (2012)

Inflammasome activation negatively regulates MyD88-IRF7 type I IFN signaling and anti-malaria immunity
por: Yu, Xiao, et al.
Publicado: (2018)

Lipopolysaccharide-induced NF-κB nuclear translocation is primarily dependent on MyD88, but TNFα expression requires TRIF and MyD88
por: Sakai, Jiro, et al.
Publicado: (2017)

Diversity and correlation analysis of endophytes and metabolites of Panax quinquefolius L. in various tissues
por: Li, Rui, et al.
Publicado: (2023)

MyD88-dependent inflammasome activation and autophagy inhibition contributes to Ehrlichia-induced liver injury and toxic shock
por: Kader, Muhamuda, et al.
Publicado: (2017)

Supplementation of Saponins from Leaves of Panax quinquefolius Mitigates Cisplatin-Evoked Cardiotoxicity via Inhibiting Oxidative Stress-Associated Inflammation and Apoptosis in Mice
por: Xing, Jing-Jing, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_1t7hkujcb1qmg5pmsa1ri2l30g