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Impact of coronavirus disease 2019 in a child who underwent ventricular septal defect device closure: a case report

BACKGROUND: Studies about the incidence and severity of coronavirus disease 2019 (COVID-19) in children are still significantly lower than those in adults. Moreover, data on the effect of COVID-19 in children with congenital heart disease (CHD) are limited. To the best of our knowledge, this study f...

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Autores principales: Bahaidarah, Saud A, Dohain, Ahmed M, Abdelmohsen, Gaser, Alnajjar, Abeer A, Al-Ata, Jameel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898581/
https://www.ncbi.nlm.nih.gov/pubmed/33644647
http://dx.doi.org/10.1093/ehjcr/ytaa478
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author Bahaidarah, Saud A
Dohain, Ahmed M
Abdelmohsen, Gaser
Alnajjar, Abeer A
Al-Ata, Jameel
author_facet Bahaidarah, Saud A
Dohain, Ahmed M
Abdelmohsen, Gaser
Alnajjar, Abeer A
Al-Ata, Jameel
author_sort Bahaidarah, Saud A
collection PubMed
description BACKGROUND: Studies about the incidence and severity of coronavirus disease 2019 (COVID-19) in children are still significantly lower than those in adults. Moreover, data on the effect of COVID-19 in children with congenital heart disease (CHD) are limited. To the best of our knowledge, this study first reported mortality in a child with CHD who acquired COVID-19. CASE SUMMARY: A 16-month-old boy presented to the emergency department due to shortness of breath, fever, cough, and poor oral intake. He tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). He required mechanical ventilation for rapidly progressing respiratory failure. The patient had a large mid-muscular ventricular septal defect (VSD) that was closed percutaneously at the age of 13 months. Moreover, we followed his hospital sequelae from admission to death. DISCUSSION: This child had multiple risk factors, including malnutrition and persistent pulmonary hypertension (PH) after late closure of the VSD. The pre-existing PH could have been aggravated by the lung condition associated with COVID-19 and the respiratory failure triggered by SARS-CoV-2 infection. The patient presented with ventricular systolic dysfunction, elevated troponin serum levels and newly developed trifascicular block, which were indicative of myocardial injury. The elevated inflammatory markers and multi-organ dysfunction seem to corroborate multisystem inflammatory syndrome in children, which was described recently among paediatric patients with COVID-19.
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spelling pubmed-78985812021-02-25 Impact of coronavirus disease 2019 in a child who underwent ventricular septal defect device closure: a case report Bahaidarah, Saud A Dohain, Ahmed M Abdelmohsen, Gaser Alnajjar, Abeer A Al-Ata, Jameel Eur Heart J Case Rep Case Report BACKGROUND: Studies about the incidence and severity of coronavirus disease 2019 (COVID-19) in children are still significantly lower than those in adults. Moreover, data on the effect of COVID-19 in children with congenital heart disease (CHD) are limited. To the best of our knowledge, this study first reported mortality in a child with CHD who acquired COVID-19. CASE SUMMARY: A 16-month-old boy presented to the emergency department due to shortness of breath, fever, cough, and poor oral intake. He tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). He required mechanical ventilation for rapidly progressing respiratory failure. The patient had a large mid-muscular ventricular septal defect (VSD) that was closed percutaneously at the age of 13 months. Moreover, we followed his hospital sequelae from admission to death. DISCUSSION: This child had multiple risk factors, including malnutrition and persistent pulmonary hypertension (PH) after late closure of the VSD. The pre-existing PH could have been aggravated by the lung condition associated with COVID-19 and the respiratory failure triggered by SARS-CoV-2 infection. The patient presented with ventricular systolic dysfunction, elevated troponin serum levels and newly developed trifascicular block, which were indicative of myocardial injury. The elevated inflammatory markers and multi-organ dysfunction seem to corroborate multisystem inflammatory syndrome in children, which was described recently among paediatric patients with COVID-19. Oxford University Press 2020-12-20 /pmc/articles/PMC7898581/ /pubmed/33644647 http://dx.doi.org/10.1093/ehjcr/ytaa478 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of the European Society of Cardiology. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Case Report
Bahaidarah, Saud A
Dohain, Ahmed M
Abdelmohsen, Gaser
Alnajjar, Abeer A
Al-Ata, Jameel
Impact of coronavirus disease 2019 in a child who underwent ventricular septal defect device closure: a case report
title Impact of coronavirus disease 2019 in a child who underwent ventricular septal defect device closure: a case report
title_full Impact of coronavirus disease 2019 in a child who underwent ventricular septal defect device closure: a case report
title_fullStr Impact of coronavirus disease 2019 in a child who underwent ventricular septal defect device closure: a case report
title_full_unstemmed Impact of coronavirus disease 2019 in a child who underwent ventricular septal defect device closure: a case report
title_short Impact of coronavirus disease 2019 in a child who underwent ventricular septal defect device closure: a case report
title_sort impact of coronavirus disease 2019 in a child who underwent ventricular septal defect device closure: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898581/
https://www.ncbi.nlm.nih.gov/pubmed/33644647
http://dx.doi.org/10.1093/ehjcr/ytaa478
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