An Unexpected Split‐Merge Pathway in the Assembly of the Symmetric Nonribosomal Peptide Antibiotic Closthioamide

Closthioamide (CTA) is a symmetric nonribosomal peptide (NRP) comprised of two diaminopropane‐linked polythioamidated monomers. CTA is biosynthesized by Ruminiclostridium cellulolyticum via an atypical NRP synthetase (NRPS)‐independent biosynthetic pathway. Although the logic for monomer assembly wa...

Descripción completa

Detalles Bibliográficos
Autores principales: Dunbar, Kyle L., Dell, Maria, Molloy, Evelyn M., Büttner, Hannah, Kumpfmüller, Jana, Hertweck, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898593/
https://www.ncbi.nlm.nih.gov/pubmed/33119936
http://dx.doi.org/10.1002/anie.202011741

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898593/
https://www.ncbi.nlm.nih.gov/pubmed/33119936
http://dx.doi.org/10.1002/anie.202011741

Ejemplares similares