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Stiffness Tomography of Ultra‐Soft Nanogels by Atomic Force Microscopy
The softness of nanohydrogels results in unique properties and recently attracted tremendous interest due to the multi‐functionalization of interfaces. Herein, we study extremely soft temperature‐sensitive ultra‐low cross‐linked (ULC) nanogels adsorbed to the solid/water interface by atomic force mi...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898630/ https://www.ncbi.nlm.nih.gov/pubmed/33459462 http://dx.doi.org/10.1002/anie.202011615 |
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author | Schulte, M. Friederike Bochenek, Steffen Brugnoni, Monia Scotti, Andrea Mourran, Ahmed Richtering, Walter |
author_facet | Schulte, M. Friederike Bochenek, Steffen Brugnoni, Monia Scotti, Andrea Mourran, Ahmed Richtering, Walter |
author_sort | Schulte, M. Friederike |
collection | PubMed |
description | The softness of nanohydrogels results in unique properties and recently attracted tremendous interest due to the multi‐functionalization of interfaces. Herein, we study extremely soft temperature‐sensitive ultra‐low cross‐linked (ULC) nanogels adsorbed to the solid/water interface by atomic force microscopy (AFM). The ultra‐soft nanogels seem to disappear in classical imaging modes since a sharp tip fully penetrates these porous networks with very low forces in the range of steric interactions (ca. 100 pN). However, the detailed evaluation of Force Volume mode measurements allows us to resolve their overall shape and at the same time their internal structure in all three dimensions. The nanogels exhibit an extraordinary disk‐like and entirely homogeneous but extremely soft structure—even softer than polymer brushes. Moreover, the temperature‐sensitive nanogels can be switched on demand between the ultra‐soft and a very stiff state. |
format | Online Article Text |
id | pubmed-7898630 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78986302021-03-03 Stiffness Tomography of Ultra‐Soft Nanogels by Atomic Force Microscopy Schulte, M. Friederike Bochenek, Steffen Brugnoni, Monia Scotti, Andrea Mourran, Ahmed Richtering, Walter Angew Chem Int Ed Engl Research Articles The softness of nanohydrogels results in unique properties and recently attracted tremendous interest due to the multi‐functionalization of interfaces. Herein, we study extremely soft temperature‐sensitive ultra‐low cross‐linked (ULC) nanogels adsorbed to the solid/water interface by atomic force microscopy (AFM). The ultra‐soft nanogels seem to disappear in classical imaging modes since a sharp tip fully penetrates these porous networks with very low forces in the range of steric interactions (ca. 100 pN). However, the detailed evaluation of Force Volume mode measurements allows us to resolve their overall shape and at the same time their internal structure in all three dimensions. The nanogels exhibit an extraordinary disk‐like and entirely homogeneous but extremely soft structure—even softer than polymer brushes. Moreover, the temperature‐sensitive nanogels can be switched on demand between the ultra‐soft and a very stiff state. John Wiley and Sons Inc. 2020-12-01 2021-02-01 /pmc/articles/PMC7898630/ /pubmed/33459462 http://dx.doi.org/10.1002/anie.202011615 Text en © 2020 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Research Articles Schulte, M. Friederike Bochenek, Steffen Brugnoni, Monia Scotti, Andrea Mourran, Ahmed Richtering, Walter Stiffness Tomography of Ultra‐Soft Nanogels by Atomic Force Microscopy |
title | Stiffness Tomography of Ultra‐Soft Nanogels by Atomic Force Microscopy |
title_full | Stiffness Tomography of Ultra‐Soft Nanogels by Atomic Force Microscopy |
title_fullStr | Stiffness Tomography of Ultra‐Soft Nanogels by Atomic Force Microscopy |
title_full_unstemmed | Stiffness Tomography of Ultra‐Soft Nanogels by Atomic Force Microscopy |
title_short | Stiffness Tomography of Ultra‐Soft Nanogels by Atomic Force Microscopy |
title_sort | stiffness tomography of ultra‐soft nanogels by atomic force microscopy |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898630/ https://www.ncbi.nlm.nih.gov/pubmed/33459462 http://dx.doi.org/10.1002/anie.202011615 |
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