Total Synthesis and Structure Revision of Halioxepine

The first total synthesis of halioxepine is accomplished using a 1,4‐addition for constructing the quaternary center at C10 and a halo etherification for the generation of the tertiary ether at C7. The correct structure of halioxepine was determined by assembling different enantiomeric building bloc...

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Detalles Bibliográficos
Autores principales: Poock, Caroline, Kalesse, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898713/
https://www.ncbi.nlm.nih.gov/pubmed/33215739
http://dx.doi.org/10.1002/chem.202004847
Descripción
Sumario:The first total synthesis of halioxepine is accomplished using a 1,4‐addition for constructing the quaternary center at C10 and a halo etherification for the generation of the tertiary ether at C7. The correct structure of halioxepine was determined by assembling different enantiomeric building blocks and by changing the relative configuration between C10 and C15.

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