Total Synthesis and Structure Revision of Halioxepine

The first total synthesis of halioxepine is accomplished using a 1,4‐addition for constructing the quaternary center at C10 and a halo etherification for the generation of the tertiary ether at C7. The correct structure of halioxepine was determined by assembling different enantiomeric building bloc...

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Detalles Bibliográficos
Autores principales: Poock, Caroline, Kalesse, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898713/
https://www.ncbi.nlm.nih.gov/pubmed/33215739
http://dx.doi.org/10.1002/chem.202004847
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author Poock, Caroline
Kalesse, Markus
author_facet Poock, Caroline
Kalesse, Markus
author_sort Poock, Caroline
collection PubMed
description The first total synthesis of halioxepine is accomplished using a 1,4‐addition for constructing the quaternary center at C10 and a halo etherification for the generation of the tertiary ether at C7. The correct structure of halioxepine was determined by assembling different enantiomeric building blocks and by changing the relative configuration between C10 and C15.
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spelling pubmed-78987132021-03-03 Total Synthesis and Structure Revision of Halioxepine Poock, Caroline Kalesse, Markus Chemistry Communications The first total synthesis of halioxepine is accomplished using a 1,4‐addition for constructing the quaternary center at C10 and a halo etherification for the generation of the tertiary ether at C7. The correct structure of halioxepine was determined by assembling different enantiomeric building blocks and by changing the relative configuration between C10 and C15. John Wiley and Sons Inc. 2020-12-22 2021-01-21 /pmc/articles/PMC7898713/ /pubmed/33215739 http://dx.doi.org/10.1002/chem.202004847 Text en © 2020 The Authors. Published by Wiley-VCH GmbH This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Communications
Poock, Caroline
Kalesse, Markus
Total Synthesis and Structure Revision of Halioxepine
title Total Synthesis and Structure Revision of Halioxepine
title_full Total Synthesis and Structure Revision of Halioxepine
title_fullStr Total Synthesis and Structure Revision of Halioxepine
title_full_unstemmed Total Synthesis and Structure Revision of Halioxepine
title_short Total Synthesis and Structure Revision of Halioxepine
title_sort total synthesis and structure revision of halioxepine
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898713/
https://www.ncbi.nlm.nih.gov/pubmed/33215739
http://dx.doi.org/10.1002/chem.202004847
work_keys_str_mv AT poockcaroline totalsynthesisandstructurerevisionofhalioxepine
AT kalessemarkus totalsynthesisandstructurerevisionofhalioxepine

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