Rapid and Selective Chemical Editing of Ribosomally Synthesized and Post‐Translationally Modified Peptides (RiPPs) via Cu(II)‐Catalyzed β‐Borylation of Dehydroamino Acids

We report the fast and selective chemical editing of ribosomally synthesized and post‐translationally modified peptides (RiPPs) by β‐borylation of dehydroalanine (Dha) residues. The thiopeptide thiostrepton was modified efficiently using Cu(II)‐catalysis under mild conditions and 1D/2D NMR of the pu...

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Detalles Bibliográficos
Autores principales: de Vries, Reinder H., Viel, Jakob H., Kuipers, Oscar P., Roelfes, Gerard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898795/
https://www.ncbi.nlm.nih.gov/pubmed/33185967
http://dx.doi.org/10.1002/anie.202011460

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