Cargando…
Effect of inhibition indexed by auditory P300 on transmission of visual sensory information
Early electroencephalographic studies that focused on finding brain correlates of psychic events led to the discovery of the P300. Since then, the P300 has become the focus of many basic and clinical neuroscience studies. However, despite its wide applications, the underlying function of the P300 is...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899349/ https://www.ncbi.nlm.nih.gov/pubmed/33617549 http://dx.doi.org/10.1371/journal.pone.0247416 |
_version_ | 1783654035977404416 |
---|---|
author | Houshmand Chatroudi, Amirmahmoud Rostami, Reza Nasrabadi, Ali Motie Yotsumoto, Yuko |
author_facet | Houshmand Chatroudi, Amirmahmoud Rostami, Reza Nasrabadi, Ali Motie Yotsumoto, Yuko |
author_sort | Houshmand Chatroudi, Amirmahmoud |
collection | PubMed |
description | Early electroencephalographic studies that focused on finding brain correlates of psychic events led to the discovery of the P300. Since then, the P300 has become the focus of many basic and clinical neuroscience studies. However, despite its wide applications, the underlying function of the P300 is not yet clearly understood. One line of research among the many studies that have attempted to elucidate the underlying subroutine of the P300 in the brain has suggested that the physiological function of the P300 is related to inhibition. While some intracranial, behavioral, and event-related potential studies have provided support for this theory, little is known about the inhibitory mechanism. In this study, using alpha event-related desynchronization (ERD) and effective connectivity, based on the causal (one-way directed) relationship between alpha ERD and P300 sources, we demonstrated that P300’s associated inhibition is implemented at a higher information processing stage in a localized brain region. We discuss how inhibition as the primary function of the P300 is not inconsistent with ’resource allocation’ and ’working memory updating’ theories about its cognitive function. In light of our findings regarding the scope and information processing stage of inhibition of the P300, we reconcile the inhibitory account of the P300 with working memory updating theory. Finally, based on the compensatory behavior of alpha ERD at the time of suppression of the P300, we propose two distinct yet complementary working memory mechanisms (inhibition and desynchronizing excitation) that render target perception possible. |
format | Online Article Text |
id | pubmed-7899349 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-78993492021-03-02 Effect of inhibition indexed by auditory P300 on transmission of visual sensory information Houshmand Chatroudi, Amirmahmoud Rostami, Reza Nasrabadi, Ali Motie Yotsumoto, Yuko PLoS One Research Article Early electroencephalographic studies that focused on finding brain correlates of psychic events led to the discovery of the P300. Since then, the P300 has become the focus of many basic and clinical neuroscience studies. However, despite its wide applications, the underlying function of the P300 is not yet clearly understood. One line of research among the many studies that have attempted to elucidate the underlying subroutine of the P300 in the brain has suggested that the physiological function of the P300 is related to inhibition. While some intracranial, behavioral, and event-related potential studies have provided support for this theory, little is known about the inhibitory mechanism. In this study, using alpha event-related desynchronization (ERD) and effective connectivity, based on the causal (one-way directed) relationship between alpha ERD and P300 sources, we demonstrated that P300’s associated inhibition is implemented at a higher information processing stage in a localized brain region. We discuss how inhibition as the primary function of the P300 is not inconsistent with ’resource allocation’ and ’working memory updating’ theories about its cognitive function. In light of our findings regarding the scope and information processing stage of inhibition of the P300, we reconcile the inhibitory account of the P300 with working memory updating theory. Finally, based on the compensatory behavior of alpha ERD at the time of suppression of the P300, we propose two distinct yet complementary working memory mechanisms (inhibition and desynchronizing excitation) that render target perception possible. Public Library of Science 2021-02-22 /pmc/articles/PMC7899349/ /pubmed/33617549 http://dx.doi.org/10.1371/journal.pone.0247416 Text en © 2021 Houshmand Chatroudi et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Houshmand Chatroudi, Amirmahmoud Rostami, Reza Nasrabadi, Ali Motie Yotsumoto, Yuko Effect of inhibition indexed by auditory P300 on transmission of visual sensory information |
title | Effect of inhibition indexed by auditory P300 on transmission of visual sensory information |
title_full | Effect of inhibition indexed by auditory P300 on transmission of visual sensory information |
title_fullStr | Effect of inhibition indexed by auditory P300 on transmission of visual sensory information |
title_full_unstemmed | Effect of inhibition indexed by auditory P300 on transmission of visual sensory information |
title_short | Effect of inhibition indexed by auditory P300 on transmission of visual sensory information |
title_sort | effect of inhibition indexed by auditory p300 on transmission of visual sensory information |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899349/ https://www.ncbi.nlm.nih.gov/pubmed/33617549 http://dx.doi.org/10.1371/journal.pone.0247416 |
work_keys_str_mv | AT houshmandchatroudiamirmahmoud effectofinhibitionindexedbyauditoryp300ontransmissionofvisualsensoryinformation AT rostamireza effectofinhibitionindexedbyauditoryp300ontransmissionofvisualsensoryinformation AT nasrabadialimotie effectofinhibitionindexedbyauditoryp300ontransmissionofvisualsensoryinformation AT yotsumotoyuko effectofinhibitionindexedbyauditoryp300ontransmissionofvisualsensoryinformation |