Phase 1 study of Z-endoxifen in patients with advanced gynecologic, desmoid, and hormone receptor-positive solid tumors

Background: Differential responses to tamoxifen may be due to inter-patient variability in tamoxifen metabolism into pharmacologically active Z-endoxifen. Z-endoxifen administration was anticipated to bypass these variations, increasing active drug levels, and potentially benefitting patients respon...

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Detalles Bibliográficos
Autores principales: Takebe, Naoko, Coyne, Geraldine O'Sullivan, Kummar, Shivaani, Collins, Jerry, Reid, Joel M., Piekarz, Richard, Moore, Nancy, Juwara, Lamin, Johnson, Barry C., Bishop, Rachel, Lin, Frank I., Mena, Esther, Choyke, Peter L., Lindenberg, M. Liza, Rubinstein, Larry V., Bonilla, Cecilia Monge, Goetz, Matthew P., Ames, Matthew M., McGovern, Renee M., Streicher, Howard, Covey, Joseph M., Doroshow, James H., Chen, Alice P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899551/
https://www.ncbi.nlm.nih.gov/pubmed/33659039
http://dx.doi.org/10.18632/oncotarget.27887

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