A critical residue in the α(1)M2–M3 linker regulating mammalian GABA(A) receptor pore gating by diazepam

Benzodiazepines (BZDs) are a class of widely prescribed psychotropic drugs that modulate activity of GABA(A) receptors (GABA(A)Rs), neurotransmitter-gated ion channels critical for synaptic transmission. However, the physical basis of this modulation is poorly understood. We explore the role of an i...

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Detalles Bibliográficos
Autores principales: Nors, Joseph W, Gupta, Shipra, Goldschen-Ohm, Marcel P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899671/
https://www.ncbi.nlm.nih.gov/pubmed/33591271
http://dx.doi.org/10.7554/eLife.64400

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