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Survival comparison between radiofrequency ablation and surgical resection for patients with small hepatocellular carcinoma: A systematic review and meta-analysis
OBJECTIVE: This study aimed to evaluate and compare the long-term therapeutic efficacy of radiofrequency ablation (RFA) versus that of surgical resection in small hepatocellular carcinoma (HCC). METHODS: Relevant articles in English from PubMed, EMBASE, and the Cochrane Library were retrieved. Poole...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899892/ https://www.ncbi.nlm.nih.gov/pubmed/33607788 http://dx.doi.org/10.1097/MD.0000000000024585 |
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author | Xuan, Dongchun Wen, Weibo Xu, Dongyuan Jin, Toufeng |
author_facet | Xuan, Dongchun Wen, Weibo Xu, Dongyuan Jin, Toufeng |
author_sort | Xuan, Dongchun |
collection | PubMed |
description | OBJECTIVE: This study aimed to evaluate and compare the long-term therapeutic efficacy of radiofrequency ablation (RFA) versus that of surgical resection in small hepatocellular carcinoma (HCC). METHODS: Relevant articles in English from PubMed, EMBASE, and the Cochrane Library were retrieved. Pooled hazard ratios (HRs) were calculated to assess the prognostic value of RFA compared with that of surgical resection. RESULTS: A total of 19 studies involving 15,071 patients were included. The combined HRs (95% confidence interval [CI]) of RFA for recurrence/relapse-free survival (RFS) and overall survival (OS) were 1.55 (95% CI = 1.29-1.86, I(2) = 72.5%) and 1.61 (95% CI = 1.29-2.01, I(2) = 60.4%), respectively, compared with surgical resection. In subgroup analyses according to study design, both RFS and OS of the prospective subgroups showed statistical significance, and no statistical heterogeneity existed between studies. CONCLUSION: Our clinical data suggest that surgical resection offers better long-term oncologic outcomes than RFA. |
format | Online Article Text |
id | pubmed-7899892 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-78998922021-02-24 Survival comparison between radiofrequency ablation and surgical resection for patients with small hepatocellular carcinoma: A systematic review and meta-analysis Xuan, Dongchun Wen, Weibo Xu, Dongyuan Jin, Toufeng Medicine (Baltimore) 4500 OBJECTIVE: This study aimed to evaluate and compare the long-term therapeutic efficacy of radiofrequency ablation (RFA) versus that of surgical resection in small hepatocellular carcinoma (HCC). METHODS: Relevant articles in English from PubMed, EMBASE, and the Cochrane Library were retrieved. Pooled hazard ratios (HRs) were calculated to assess the prognostic value of RFA compared with that of surgical resection. RESULTS: A total of 19 studies involving 15,071 patients were included. The combined HRs (95% confidence interval [CI]) of RFA for recurrence/relapse-free survival (RFS) and overall survival (OS) were 1.55 (95% CI = 1.29-1.86, I(2) = 72.5%) and 1.61 (95% CI = 1.29-2.01, I(2) = 60.4%), respectively, compared with surgical resection. In subgroup analyses according to study design, both RFS and OS of the prospective subgroups showed statistical significance, and no statistical heterogeneity existed between studies. CONCLUSION: Our clinical data suggest that surgical resection offers better long-term oncologic outcomes than RFA. Lippincott Williams & Wilkins 2021-02-19 /pmc/articles/PMC7899892/ /pubmed/33607788 http://dx.doi.org/10.1097/MD.0000000000024585 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) |
spellingShingle | 4500 Xuan, Dongchun Wen, Weibo Xu, Dongyuan Jin, Toufeng Survival comparison between radiofrequency ablation and surgical resection for patients with small hepatocellular carcinoma: A systematic review and meta-analysis |
title | Survival comparison between radiofrequency ablation and surgical resection for patients with small hepatocellular carcinoma: A systematic review and meta-analysis |
title_full | Survival comparison between radiofrequency ablation and surgical resection for patients with small hepatocellular carcinoma: A systematic review and meta-analysis |
title_fullStr | Survival comparison between radiofrequency ablation and surgical resection for patients with small hepatocellular carcinoma: A systematic review and meta-analysis |
title_full_unstemmed | Survival comparison between radiofrequency ablation and surgical resection for patients with small hepatocellular carcinoma: A systematic review and meta-analysis |
title_short | Survival comparison between radiofrequency ablation and surgical resection for patients with small hepatocellular carcinoma: A systematic review and meta-analysis |
title_sort | survival comparison between radiofrequency ablation and surgical resection for patients with small hepatocellular carcinoma: a systematic review and meta-analysis |
topic | 4500 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899892/ https://www.ncbi.nlm.nih.gov/pubmed/33607788 http://dx.doi.org/10.1097/MD.0000000000024585 |
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