Cargando…
miR-224-5p-enriched exosomes promote tumorigenesis by directly targeting androgen receptor in non-small cell lung cancer
Non-small cell lung cancer (NSCLC) is the most common form of cancer, resulting in cancer-related deaths worldwide. Exosomes, a subclass of extracellular vesicles, are produced and secreted from various types of cells, including cancer cells. Cancer-derived exosomes can deliver nucleic acids, protei...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Gene & Cell Therapy
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899953/ https://www.ncbi.nlm.nih.gov/pubmed/33664999 http://dx.doi.org/10.1016/j.omtn.2021.01.028 |
_version_ | 1783654118560104448 |
---|---|
author | Zhou, Jinbao Wang, Hongshu Sun, Qiangling Liu, Xiaomin Wu, Zong Wang, Xianyi Fang, Wentao Ma, Zhongliang |
author_facet | Zhou, Jinbao Wang, Hongshu Sun, Qiangling Liu, Xiaomin Wu, Zong Wang, Xianyi Fang, Wentao Ma, Zhongliang |
author_sort | Zhou, Jinbao |
collection | PubMed |
description | Non-small cell lung cancer (NSCLC) is the most common form of cancer, resulting in cancer-related deaths worldwide. Exosomes, a subclass of extracellular vesicles, are produced and secreted from various types of cells, including cancer cells. Cancer-derived exosomes can deliver nucleic acids, proteins, and lipids to provide a favorable microenvironment that supports tumor growth through enhancing cell proliferation and metastasis. Our results showed that miR-224-5p was upregulated in NSCLC patient tissues and cell lines, with a tumor-promoting phenotype. Meanwhile, exosome-derived miR-224-5p induced cell proliferation and metastasis in NSCLC and human lung cells. Moreover, we characterized the androgen receptor (AR) as a direct target of miR-224-5p. Tumor xenograft assay experiments revealed that overexpression of miR-224-5p drove NSCLC tumor growth via the suppression of AR and the mediation of epithelial-mesenchymal transition (EMT). Collectively, our results suggest that miR-224-5p-enriched exosomes promote tumorigenesis by directly targeting AR in NSCLC, which may provide novel potential therapeutic and preventive targets for NSCLC. |
format | Online Article Text |
id | pubmed-7899953 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | American Society of Gene & Cell Therapy |
record_format | MEDLINE/PubMed |
spelling | pubmed-78999532021-03-03 miR-224-5p-enriched exosomes promote tumorigenesis by directly targeting androgen receptor in non-small cell lung cancer Zhou, Jinbao Wang, Hongshu Sun, Qiangling Liu, Xiaomin Wu, Zong Wang, Xianyi Fang, Wentao Ma, Zhongliang Mol Ther Nucleic Acids Original Article Non-small cell lung cancer (NSCLC) is the most common form of cancer, resulting in cancer-related deaths worldwide. Exosomes, a subclass of extracellular vesicles, are produced and secreted from various types of cells, including cancer cells. Cancer-derived exosomes can deliver nucleic acids, proteins, and lipids to provide a favorable microenvironment that supports tumor growth through enhancing cell proliferation and metastasis. Our results showed that miR-224-5p was upregulated in NSCLC patient tissues and cell lines, with a tumor-promoting phenotype. Meanwhile, exosome-derived miR-224-5p induced cell proliferation and metastasis in NSCLC and human lung cells. Moreover, we characterized the androgen receptor (AR) as a direct target of miR-224-5p. Tumor xenograft assay experiments revealed that overexpression of miR-224-5p drove NSCLC tumor growth via the suppression of AR and the mediation of epithelial-mesenchymal transition (EMT). Collectively, our results suggest that miR-224-5p-enriched exosomes promote tumorigenesis by directly targeting AR in NSCLC, which may provide novel potential therapeutic and preventive targets for NSCLC. American Society of Gene & Cell Therapy 2021-02-03 /pmc/articles/PMC7899953/ /pubmed/33664999 http://dx.doi.org/10.1016/j.omtn.2021.01.028 Text en © 2021 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Zhou, Jinbao Wang, Hongshu Sun, Qiangling Liu, Xiaomin Wu, Zong Wang, Xianyi Fang, Wentao Ma, Zhongliang miR-224-5p-enriched exosomes promote tumorigenesis by directly targeting androgen receptor in non-small cell lung cancer |
title | miR-224-5p-enriched exosomes promote tumorigenesis by directly targeting androgen receptor in non-small cell lung cancer |
title_full | miR-224-5p-enriched exosomes promote tumorigenesis by directly targeting androgen receptor in non-small cell lung cancer |
title_fullStr | miR-224-5p-enriched exosomes promote tumorigenesis by directly targeting androgen receptor in non-small cell lung cancer |
title_full_unstemmed | miR-224-5p-enriched exosomes promote tumorigenesis by directly targeting androgen receptor in non-small cell lung cancer |
title_short | miR-224-5p-enriched exosomes promote tumorigenesis by directly targeting androgen receptor in non-small cell lung cancer |
title_sort | mir-224-5p-enriched exosomes promote tumorigenesis by directly targeting androgen receptor in non-small cell lung cancer |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899953/ https://www.ncbi.nlm.nih.gov/pubmed/33664999 http://dx.doi.org/10.1016/j.omtn.2021.01.028 |
work_keys_str_mv | AT zhoujinbao mir2245penrichedexosomespromotetumorigenesisbydirectlytargetingandrogenreceptorinnonsmallcelllungcancer AT wanghongshu mir2245penrichedexosomespromotetumorigenesisbydirectlytargetingandrogenreceptorinnonsmallcelllungcancer AT sunqiangling mir2245penrichedexosomespromotetumorigenesisbydirectlytargetingandrogenreceptorinnonsmallcelllungcancer AT liuxiaomin mir2245penrichedexosomespromotetumorigenesisbydirectlytargetingandrogenreceptorinnonsmallcelllungcancer AT wuzong mir2245penrichedexosomespromotetumorigenesisbydirectlytargetingandrogenreceptorinnonsmallcelllungcancer AT wangxianyi mir2245penrichedexosomespromotetumorigenesisbydirectlytargetingandrogenreceptorinnonsmallcelllungcancer AT fangwentao mir2245penrichedexosomespromotetumorigenesisbydirectlytargetingandrogenreceptorinnonsmallcelllungcancer AT mazhongliang mir2245penrichedexosomespromotetumorigenesisbydirectlytargetingandrogenreceptorinnonsmallcelllungcancer |