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Role of Sphingosine Kinase in Type 2 Diabetes Mellitus

Sphingolipids are a class of essential lipids, functioning as both cell membrane constituents and signaling messengers. In the sphingolipid metabolic network, ceramides serve as the central hub that is hydrolyzed to sphingosine, followed by phosphorylation to sphingosine 1-phosphate (S1P) by sphingo...

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Autores principales: Qi, Yanfei, Wang, Wei, Song, Ziyu, Aji, Gulibositan, Liu, Xin Tracy, Xia, Pu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899982/
https://www.ncbi.nlm.nih.gov/pubmed/33633691
http://dx.doi.org/10.3389/fendo.2020.627076
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author Qi, Yanfei
Wang, Wei
Song, Ziyu
Aji, Gulibositan
Liu, Xin Tracy
Xia, Pu
author_facet Qi, Yanfei
Wang, Wei
Song, Ziyu
Aji, Gulibositan
Liu, Xin Tracy
Xia, Pu
author_sort Qi, Yanfei
collection PubMed
description Sphingolipids are a class of essential lipids, functioning as both cell membrane constituents and signaling messengers. In the sphingolipid metabolic network, ceramides serve as the central hub that is hydrolyzed to sphingosine, followed by phosphorylation to sphingosine 1-phosphate (S1P) by sphingosine kinase (SphK). SphK is regarded as a “switch” of the sphingolipid rheostat, as it catalyzes the conversion of ceramide/sphingosine to S1P, which often exhibit opposing biological roles in the cell. Besides, SphK is an important signaling enzyme that has been implicated in the regulation of a wide variety of biological functions. In recent years, an increasing body of evidence has suggested a critical role of SphK in type 2 diabetes mellitus (T2D), although a certain level of controversy remains. Herein, we review recent findings related to SphK in the field of T2D research with a focus on peripheral insulin resistance and pancreatic β-cell failure. It is expected that a comprehensive understanding of the role of SphK and the associated sphingolipids in T2D will help to identify druggable targets for future anti-diabetes therapy.
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spelling pubmed-78999822021-02-24 Role of Sphingosine Kinase in Type 2 Diabetes Mellitus Qi, Yanfei Wang, Wei Song, Ziyu Aji, Gulibositan Liu, Xin Tracy Xia, Pu Front Endocrinol (Lausanne) Endocrinology Sphingolipids are a class of essential lipids, functioning as both cell membrane constituents and signaling messengers. In the sphingolipid metabolic network, ceramides serve as the central hub that is hydrolyzed to sphingosine, followed by phosphorylation to sphingosine 1-phosphate (S1P) by sphingosine kinase (SphK). SphK is regarded as a “switch” of the sphingolipid rheostat, as it catalyzes the conversion of ceramide/sphingosine to S1P, which often exhibit opposing biological roles in the cell. Besides, SphK is an important signaling enzyme that has been implicated in the regulation of a wide variety of biological functions. In recent years, an increasing body of evidence has suggested a critical role of SphK in type 2 diabetes mellitus (T2D), although a certain level of controversy remains. Herein, we review recent findings related to SphK in the field of T2D research with a focus on peripheral insulin resistance and pancreatic β-cell failure. It is expected that a comprehensive understanding of the role of SphK and the associated sphingolipids in T2D will help to identify druggable targets for future anti-diabetes therapy. Frontiers Media S.A. 2021-02-09 /pmc/articles/PMC7899982/ /pubmed/33633691 http://dx.doi.org/10.3389/fendo.2020.627076 Text en Copyright © 2021 Qi, Wang, Song, Aji, Liu and Xia http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Qi, Yanfei
Wang, Wei
Song, Ziyu
Aji, Gulibositan
Liu, Xin Tracy
Xia, Pu
Role of Sphingosine Kinase in Type 2 Diabetes Mellitus
title Role of Sphingosine Kinase in Type 2 Diabetes Mellitus
title_full Role of Sphingosine Kinase in Type 2 Diabetes Mellitus
title_fullStr Role of Sphingosine Kinase in Type 2 Diabetes Mellitus
title_full_unstemmed Role of Sphingosine Kinase in Type 2 Diabetes Mellitus
title_short Role of Sphingosine Kinase in Type 2 Diabetes Mellitus
title_sort role of sphingosine kinase in type 2 diabetes mellitus
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899982/
https://www.ncbi.nlm.nih.gov/pubmed/33633691
http://dx.doi.org/10.3389/fendo.2020.627076
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