HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation

N6-methyladenosine (m6A), and its reader protein YTHDF1, play a pivotal role in human tumorigenesis by affecting nearly every stage of RNA metabolism. Autophagy activation is one of the ways by which cancer cells survive hypoxia. However, the possible involvement of m6A modification of mRNA in hypox...

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Detalles Bibliográficos
Autores principales: Li, Qing, Ni, Yong, Zhang, Liren, Jiang, Runqiu, Xu, Jing, Yang, Hong, Hu, Yuanchang, Qiu, Jiannan, Pu, Liyong, Tang, Jinhai, Wang, Xuehao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7900110/
https://www.ncbi.nlm.nih.gov/pubmed/33619246
http://dx.doi.org/10.1038/s41392-020-00453-8

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