Alterations in the HLA-B*57:01 Immunopeptidome by Flucloxacillin and Immunogenicity of Drug-Haptenated Peptides

Neoantigen formation due to the interaction of drug molecules with human leukocyte antigen (HLA)-peptide complexes can lead to severe hypersensitivity reactions. Flucloxacillin (FLX), a β-lactam antibiotic for narrow-spectrum gram-positive bacterial infections, has been associated with severe immune...

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Detalles Bibliográficos
Autores principales: Puig, Montserrat, Ananthula, Suryatheja, Venna, Ramesh, Kumar Polumuri, Swamy, Mattson, Elliot, Walker, Lacey M., Cardone, Marco, Takahashi, Mayumi, Su, Shan, Boyd, Lisa F., Natarajan, Kannan, Abdoulaeva, Galina, Wu, Wells W., Roderiquez, Gregory, Hildebrand, William H., Beaucage, Serge L., Li, Zhihua, Margulies, David H., Norcross, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7900192/
https://www.ncbi.nlm.nih.gov/pubmed/33633747
http://dx.doi.org/10.3389/fimmu.2020.629399

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